ArticleFrontiers in medicine2025
New intervention strategy for postoperative fatigue syndrome in elderly patients with colorectal cancer: a clinical hypothesis study based on vagus nerve stimulation.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Knowledge, attitudes, and practices toward postoperative fatigue syndrome among postoperative patients.Scientific reports · 2026Article
- The perioperative brain-heart-immune axis: autonomic resilience, multimodal monitoring and postoperative delirium.Frontiers in medicine · 2026Review
- Effect of Dexmedetomidine Combined with Esketamine on Postoperative Fatigue in Patients Undergoing Total Laparoscopic Hysterectomy: A Single-Center Randomized Double-Blinded Controlled Trial.Therapeutics and clinical risk management · 2026Article
- Cholinergic reflex control of inflammation: mechanistic and translational advances in transcutaneous auricular vagus nerve stimulation across rheumatic, metabolic, and postoperative disorders.Frontiers in immunology · 2025Review
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Authors and funding
16 authors.
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Abstract
Postoperative fatigue syndrome (POFS) comprises symptoms including fatigue, insomnia, inattention, depression, tension, and anxiety following surgery. These manifestations encompass exhaustion, weakness, malaise, and emotional disturbances, impacting hospital stay duration, quality of life, rehabilitation progress, and work performance. While the etiology of POFS remains complex, recent evidence suggests that external stimuli may induce pro-inflammatory cytokine release, leading to fatigue. Surgical procedures trigger an inflammatory reaction that stimulates the nervous system, generating fatigue symptoms. Both animal and human studies demonstrate that vagus nerve stimulation (VNS) can reduce pro-inflammatory cytokine production by activating the cholinergic anti-inflammatory pathway (CAP). Considering the pivotal role of inflammation in the development of POFS and the vagus nerve's capacity to modulate inflammatory responses, we hypothesize that transcutaneous auricular vagus nerve stimulation (taVNS) holds significant potential for alleviating POFS in elderly patients undergoing colorectal cancer surgery. In this paper, we propose a hypothetical scheme to validate this hypothesis through the application of taVNS in future clinical studies.
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