ArticleOphthalmology science
Diminished MYCN Dosage Endows Cavitary Transformation in Retinoblastoma.
Article in Ophthalmology science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Targeting MYCN Degradation by HLB-0532259 Induces Senescence in Retinoblastoma.Investigative ophthalmology & visual science · 2026Article
- MYC in Oncogenesis and Therapeutic Implications.MedComm · 2026Review
- Cavitary retinoblastoma: Clinical features and treatment outcomes.Indian journal of ophthalmology · 2026Article
- Comparative Proteomic Profiling of Microdissected Spindle and Epithelioid Uveal Melanoma Subtypes.Investigative ophthalmology & visual science · 2026Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Cavitary retinoblastoma (CRB) represents a unique variant of retinoblastoma (RB) distinguished by the presence of translucent cavities, which are discernible through ophthalmoscopic examination. The present study was designed to elucidate the clinical implications and molecular signatures of CRB, thereby enhancing our understanding of this distinct subtype of RB. Design: A multicentric, nested case-control, retrospective cohort study combining spatial proteomic analysis. Participants: In a longitudinal study encompassing 1360 RB patients, conducted over a 13-year timeframe from June 2008 to February 2022, cavitary spaces were detected within the tumors of 48 eyes of 46 patients. A control cohort of 180 eyes from 138 age-matched patients with non-CRB was selected, maintaining a 1:3 case-control ratio. Laser-captured spatial proteomic analysis was conducted to explore the pivotal molecular changes within this specific subtype. The silencing of MYCN was achieved using adeno-associated virus (AAV) 2-mediated gene therapy in patient-derived xenograft models. Intervention: Enucleation, chemotherapy, and focal therapy. Main Outcome Measures: Overall survival and metastasis-free survival. Results: Cavitary RB was linked to enhanced metastasis-free survival ( Conclusions: This study establishes a novel genetic-phenotypic association, revealing that diminished MYCN expression induces the formation of translucent cavities. This phenotype is indicative of a less aggressive, well-differentiated CRB subtype with a more favorable prognosis. Financial Disclosures: The author(s) have no proprietary or commercial interest in any materials discussed in this article.
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