ArticleACS medicinal chemistry letters2025
New Triazolopyrimidines with Improved Activity against
Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Access to Pyrazolo[1,5-Organic letters · 2026Article
- Structure-Activity Relationship Study of Benzamides asACS medicinal chemistry letters · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tuberculosis is a major health crisis, and new drugs are required. We previously identified a triazolopyrimidine series with antitubercular activity acting via inhibition of the terminal cytochrome oxidase (QcrB). We conducted further exploration of the series to improve the potency and physicochemical properties. We synthesized new analogues using a 3-step synthesis: (i) condensation of an amino-pyrazole with 1,3-diketones or β-ketoester; (ii) conversion of the hydroxyl group to chloride; and (iii) S
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.