Evidence map›Paper›PMID 40528968›Full record

ReviewFundamental research2025

Advances in human organs-on-chips and applications for drug screening and personalized medicine.

Chenyang Zhou, Zhangjie Li, Kangyi Lu, Yijun Liu, Lian Xuan, Hongju Mao, Xiaolin Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Fundamental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Exploiting Device Deformability for Fluid and Particle Manipulation.Small (Weinheim an der Bergstrasse, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chenyang ZhouDepartment of Micro/Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Zhangjie LiDepartment of Micro/Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Kangyi LuDepartment of Micro/Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Yijun LiuDepartment of Micro/Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Lian XuanInstitute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200240, China.
Hongju MaoState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Xiaolin WangDepartment of Micro/Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The limitations of conventional animal tests and two-dimensional cell culture hinder their advancement in fundamental research and clinical/translational applications. As an emerging alternative technology, organ-on-a-chip serves as a platform that faithfully simulates the key phenotypical, physiological, and functional features of human tissues/organs through the accurate regulation of the parameters such as physical and biochemical microenvironment, as well as cellular patterns. In this review, we mainly introduce the recent progress in the organ-on-a-chip field, including lung, gut, heart, liver, vasculature and multiorgan studies. Furthermore, we highlight the potential applications in drug screening and personalized medicine. Finally, we conclude the review by addressing the current challenges and future perspective in the technology and commercialization of organ-on-chips. We anticipate that the development of organ-on-a-chip technology will revolutionize the studies on biology and medicine by providing new understanding of mechanisms of diseases and insights into clinical therapeutics.

Indexed as

Drug screeningMicrofluidicsOrganoidOrgan-on-a-chipPersonalized medicine

Identifiers

PMID40528968
PMCPMC12167889

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.