ArticleAntimicrobial stewardship & healthcare epidemiology : ASHE2025
Does serial procalcitonin monitoring predict clinical outcomes in children with sepsis? A diagnostic stewardship study.
Article in Antimicrobial stewardship & healthcare epidemiology : ASHE, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Prognostic utility of procalcitonin and lactate clearance for in-hospital mortality in sepsis.Frontiers in medicine · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To determine if the initial procalcitonin level and the serial trend of procalcitonin levels in blood were predictive of clinical outcomes in children with sepsis. Design: A retrospective cohort study. Setting: One primary-to-quaternary care pediatric healthcare system from May 2020 to May 2022. Participants: Encounters for children 1 to 18 years old with a sepsis ICD-10 diagnosis code and clinical sepsis were included. Methods: Procalcitonin clearance at 48 hours (CL-PCT Results: 320 unique encounters met the clinical criteria of sepsis with at least two procalcitonin values. 187 encounters had procalcitonin collected at eligible times. The mean age of the participants was 9 years and 8 months, 103 (55%) were male, and 74 (40%) were Hispanic. 78 (41.7%) individuals had good early clinical response, and 177 (94.7%) survived. There was no correlation identified between CL--PCT Conclusion: Procalcitonin clearance at 48 hours after admission did not predict early clinical stability in children with sepsis.
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