Evidence map›Paper›PMID 40528900›Full record

ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025

Association of Visceral Adiposity with Nephropathy in Patients with Diabetes Mellitus: Data from Chinese and US Cohorts.

Fan Zhang, Wenjian Li

Abstract read
In one paragraph

Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Fan ZhangDepartment of Endocrinology, Changzhou Third People's Hospital, Changzhou, Jiangsu, People's Republic of China.ORCID 0000-0001-9028-6185
Wenjian LiDepartment of Urology, Changzhou Third People's Hospital, Changzhou, Jiangsu, People's Republic of China.ORCID 0000-0002-7650-8842

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study examined the relationship between the visceral adiposity index (VAI) and diabetic nephropathy (DN) in patients with diabetes mellitus in two cohorts from China and the United States. Patients and Methods: After screening, 1,949 Chinese participants and 7,158 US participants were included in the analysis. Logistic regression models examined the relationship between VAI and DN. Concurrently, the restricted cubic spline (RCS) model was utilized to investigate the potential nonlinear relationship between VAI and DN. Additionally, segmented logistic regression analysis and subgroup analysis were conducted. Results: In both cohorts, each unit increase in VAI was associated with a higher prevalence of DN, with a 4% increase (OR=1.04, P<0.001) observed in the Chinese cohort compared to a 3% rise (OR=1.03, P<0.001) in the US cohort. The RCS analysis revealed a nonlinear relationship between VAI and DN, with an inflection point identified at 5. The results of the subgroup analyses demonstrated that the positive correlation between VAI and DN was observed across diverse subgroups. However, the interaction between some subgroups indicated the presence of potential heterogeneity. Conclusion: A significant positive association was observed between visceral adiposity and DN. Further research is required to elucidate the precise mechanisms by which visceral adiposity and DN are associated and to validate these findings in more diverse populations.

Indexed as

diabetes mellitusinflection pointnephropathyvisceral adiposity index

Identifiers

PMID40528900
PMCPMC12170839

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.