Evidence map›Paper›PMID 40528888›Full record

ReviewInnovation (Cambridge (Mass.))2025

Untethered miniature robots for minimally invasive thrombus treatment: From bench to clinical trials.

Qinglong Wang, Fangling Zhao, Ben Wang, Kai Fung Chan, Bonaventure Yiu Ming Ip, Thomas Wai Hong Leung, Xin Song, Li Zhang, Jue Xie

Abstract readReview
In one paragraph

Review in Innovation (Cambridge (Mass.)), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Soft robotic devices for cardiovascular medicine.Nature reviews. Cardiology · 2026
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Micro/Nanorobots for Combating Brain Disorders: Challenges, Advances, and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qinglong WangDepartment of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Shatin N.T., Hong Kong SAR 999077, China.
Fangling ZhaoDepartment of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Ben WangCollege of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518055, China.
Kai Fung ChanLi Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin N.T., Hong Kong SAR 999077, China.
Bonaventure Yiu Ming IpDepartment of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin N.T., Hong Kong SAR 999077, China.
Thomas Wai Hong LeungDepartment of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin N.T., Hong Kong SAR 999077, China.
Xin SongDepartment of Biomedical Engineering, City University of Hong Kong, Kowloon Tong, Kowloon, Hong Kong SAR 999077, China.
Li ZhangDepartment of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Shatin N.T., Hong Kong SAR 999077, China.
Jue XieDepartment of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Untethered miniature robots (MRs) offer a minimally invasive way to address adverse vascular blockages, such as cerebrovascular thromboembolism, myocardial infarction, and pulmonary embolism. This review explores three key questions: what are the design principles of MRs from both engineering and clinical perspectives? How can visible intervention of MRs in three-dimensional (3D) branched vessels be achieved? What is the clinical procedure for treating thrombus using designed MRs? Recent progress in MRs for thrombus removal is summarized, and, more importantly, the pros and cons of MRs are discussed. We also evaluate the challenges that may hinder their clinical deployment and propose future research directions, bridging the gap between the bench and the bedside.

Indexed as

clinical trialminiature robotsminimally invasive interventionthrombus treatment

Identifiers

PMID40528888
PMCPMC12169274

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.