Evidence map›Paper›PMID 40528718›Full record

ArticleChembiochem : a European journal of chemical biology2025

Poly(ethylene Glycol)-Based Peptidomimetics (Pegtides) of Antimicrobial Peptides.

Conor Shine, John R F B Connolly, Robert D Murphy, Hazel Lafferty, Abdalmalek Alfnikh, Ned P Buijs, Hawraa Shahrour, Nathaniel I Martin, Eoghan O'Neill, George Amarandei and 4 more

Abstract read
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In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Conor ShineDepartment of Chemistry, RCSI University of Medicine and Health Sciences, 123, St. Stephen's Green, Dublin 2, D02 YN77, Ireland.
John R F B ConnollyDepartment of Chemistry, RCSI University of Medicine and Health Sciences, 123, St. Stephen's Green, Dublin 2, D02 YN77, Ireland.
Robert D MurphyDepartment of Chemistry, RCSI University of Medicine and Health Sciences, 123, St. Stephen's Green, Dublin 2, D02 YN77, Ireland.
Hazel LaffertyDepartment of Chemistry, RCSI University of Medicine and Health Sciences, 123, St. Stephen's Green, Dublin 2, D02 YN77, Ireland.
Abdalmalek AlfnikhDepartment of Chemistry, RCSI University of Medicine and Health Sciences, 123, St. Stephen's Green, Dublin 2, D02 YN77, Ireland.
Ned P BuijsBiological Chemistry Group, Institute of Biology Leiden, Leiden University, Sylviusweg 72, Leiden, 2333 BE, The Netherlands.
Hawraa ShahrourDepartment of Microbiology, RCSI University of Medicine and Health Sciences, RCSI Education & Research Centre, Beaumont Hospital, Dublin 9, D09 YD60, Beaumont, Ireland.
Nathaniel I MartinBiological Chemistry Group, Institute of Biology Leiden, Leiden University, Sylviusweg 72, Leiden, 2333 BE, The Netherlands.
Eoghan O'NeillDepartment of Microbiology, RCSI University of Medicine and Health Sciences, RCSI Education & Research Centre, Beaumont Hospital, Dublin 9, D09 YD60, Beaumont, Ireland.
George AmarandeiThe Group of Applied Physics & School of Physics, Clinical and Optometric Sciences, Technological University Dublin, City Campus, Central Quad, Grangegorman Lower, Dublin 7, D07 ADY7, Ireland.
Jimmy MuldoonSchool of Chemistry, University College Dublin, Belfield, Dublin 4, D04 N2E5, Ireland.
Marc MarescaAix Marseille University, CNRS, Centrale Med, ISM2, 13013, Marseille, France.
Deirdre Fitzgerald-HughesDepartment of Microbiology, RCSI University of Medicine and Health Sciences, RCSI Education & Research Centre, Beaumont Hospital, Dublin 9, D09 YD60, Beaumont, Ireland.
Marc DevocelleDepartment of Chemistry, RCSI University of Medicine and Health Sciences, 123, St. Stephen's Green, Dublin 2, D02 YN77, Ireland.ORCID https://orcid.org/0000-0001-7641-1306

Funding

Research Ireland 19/FFP/6889Science Foundation Ireland 16/RI/3737Science Foundation Ireland 18/RI/5702
6 · The paper itself

Abstract

Cationic amphipathic poly(ethylene glycol)-based polymers are generated with synthetic efficiencies allowing their evaluation as antimicrobial peptide (AMP) mimetics. Accordingly, statistical copolymers with cationic units consistently functionalized with guanyl groups, but different side-chain lengths, and hydrophobic units displaying long aliphatic, branched, and/or aromatic side chains are produced and tested for their antimicrobial and hemolytic properties. The results obtained indicate that candidates with activities and selectivity commensurate to some AMPs can be obtained and that further development of this novel type of antimicrobial peptidomimetics, pegtides, is warranted for clinical and/or biotechnological applications.

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsAntimicrobial PeptidesPeptidomimeticsPolyethylene GlycolsErythrocytesHemolysisHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsAnti-Infective AgentsAntimicrobial PeptidesPeptidomimeticsPolyethylene Glycolsantimicrobial peptidescationic amphipathic copolymersfunctionalized poly(ethylene glycol)pegtidespeptidomimetics

Identifiers

PMID40528718
PMCPMC12596929

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.