Evidence map›Paper›PMID 40528706›Full record

ReviewAngewandte Chemie (International ed. in English)2025

The Chemistry and Biology of the Tetrodotoxin Natural Product Family.

Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B Konrad

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Identification of Deoxy- andJournal of natural products · 2026
    Article
  2. Review
  3. The Chemistry and Biology of the Tetrodotoxin Natural Product Family.Angewandte Chemie (International ed. in English) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Benedikt NißlDepartment of Pharmacy, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, Haus C, 81377, Munich, Germany.
Marcel MülbaierDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078, Aachen, Germany.
Francesca GrisoniBiomedical Engineering Department, Eindhoven University of Technology, Groene Loper 3, Eindhoven, The Netherlands.
Dirk TraunerDepartment of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA, 19104-6323, USA.
Marcel BermúdezInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster, Corrensstr. 48, 48149, Münster, Germany.
Clemens DialerDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078, Aachen, Germany.
David B KonradDepartment of Pharmacy, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, Haus C, 81377, Munich, Germany.ORCID 0000-0001-5718-8081

Funding

Bundesministerium für Bildung, Wissenschaft, Forschung und TechnologieFonds der Chemischen Industrie Liebig Fellowship
6 · The paper itself

Abstract

Tetrodotoxin is a neurotoxic marine alkaloid, first isolated in 1909 from pufferfish and named after the biological order tetraodontiformes. Since its structural elucidation in 1964, it has attracted the interest of synthetic organic chemists due to its exceptional polarity, complex architecture, and important biological activity. This review highlights the diversity of the tetrodotoxin natural product family and discusses the origins of derivatives, biosynthetic hypotheses, and biological activities. Furthermore, potential therapeutic applications and structure-activity relationship studies are covered, along with the total syntheses of the natural product and selected derivatives that were published to date.

Indexed as

Biological ProductsTetrodotoxinAnimalsHumansMolecular StructureStructure-Activity RelationshipBiological ProductsTetrodotoxinChemical probesMedicinal chemistryNociceptionTotal synthesisVoltage‐gated sodium channels

Identifiers

PMID40528706
PMCPMC12377457

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.