Observational studyTherapeutic advances in respiratory disease
Association between early intubation and mortality in patients at high risk for noninvasive ventilation failure: a propensity-matched cohort study.
Observational study in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Identification of physiological clusters in acute hypoxemic respiratory failure patients undergoing non-invasive respiratory support using EIT-based t-SNE and spectral clustering.Intensive care medicine experimental · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNoninvasive ventilation (NIV) is frequently employed for acute hypoxemic respiratory failure, yet optimal intubation timing for high-risk NIV failure patients remains uncertain.
objectivesTo investigate mortality outcomes associated with early versus late intubation in high-risk NIV failure patients.
designSecondary analysis of a multicenter observational cohort study.
methodsPatients with high NIV failure risk (updated HACOR score ⩾11 after 1-2 h of NIV) were enrolled. We defined that intubation was needed in these high-risk patients. Intubation occurring within 12 h of NIV initiation was classified as early intubation, while intubation after 12 h was designated as late intubation. Primary outcomes were intensive care unit (ICU) and hospital mortality. In sensitivity analyses, patients who achieved NIV success were categorized into the late-intubation group. Due to baseline imbalances, propensity score matching was performed with covariate adjustment.
resultsAmong the study population, 171 patients underwent early intubation and 222 underwent late intubation. Despite greater baseline severity in the early intubation group, ICU mortality (36% vs 58%,
conclusionIn patients at high risk for NIV failure, early intubation is associated with reduced mortality.
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