ArticleHistopathology2025
Assessment and classification of sex cord-stromal tumours of the testis: recommendations from the testicular sex cord-stromal tumour (TESST) group, an Expert Panel of the Genitourinary Pathology Society (GUPS) and International Society of Urological Pathology (ISUP).
Article in Histopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guideline
- ALK Expression Without ALK Rearrangement in EWSR1::ATF1-Fused Inflammatory and Nested Testicular Sex Cord Tumor.Diagnostics (Basel, Switzerland) · 2026Article
- Azoospermia, Atrophy, and Asymmetry: Unilateral Sertoli Cell Tumor as a Rare and Overlooked Cause of Male Infertility: A Case Report and Literature Review.Clinical case reports · 2026Article
- FGFR1 mutations identified in FOXL2-wild type ovarian adult granulosa cell tumors are not present in testicular counterparts: Re-analysis of a multi-institutional series.Virchows Archiv : an international journal of pathology · 2026Article
- Characterizing Paratesticular Neoplasms in Proteus Syndrome.The American journal of surgical pathology · 2026Article
- Adult granulosa cell tumours of the testis analogous to ovarian counterparts are exceptionally rare: analysis of a multicentric series and review of the literature.Histopathology · 2026Review
- Advances in non-germ cell tumours of the testis: focus on new molecular developments in sex cord-stromal tumours.Histopathology · 2026Review
- MicroRNA profiling of testicular Leydig cell tumors identifies a microRNA signature associated with malignancy and miR-196b-5p as a potentially useful biomarker.The Journal of pathology · 2026Article
- Complete androgen insensitivity syndrome with cryptorchid sertoli cell tumor: a case report and literature review.Frontiers in medicine · 2026Article
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Authors and funding
22 authors.
Funding
Abstract
aimsTesticular sex cord-stromal tumours (TSCSTs) are relatively rare, accounting for ~5% of all testicular neoplasms. They were historically classified into Leydig cell tumour, Sertoli cell tumour, granulosa cell tumour, and unclassified sex cord-stromal tumour. More recently, classification was expanded to incorporate additional histologic types, including some associated with inherited cancer predisposition syndromes. However, the classification of TSCSTs still relies entirely on morphology, with some tumour types being defined based on their resemblance to ovarian counterparts. In recent years, molecular studies have identified drivers and genomic alterations associated with aggressive behaviour and progression; however, these findings have not yet impacted classification and management. METHODS AND
resultsUnder sponsorship of the International Society of Urological Pathology (ISUP) and the Genitourinary Pathology Society (GUPS), a group of genitourinary pathologists was assembled in 2023 with the aim of assessing how to use these new data to improve the classification and management of TSCSTs.
conclusionsThis paper summarizes the recommendations derived from the consensus activities and the first meeting of the testicular sex cord-stromal tumour (TESST) group (held at Johns Hopkins Hospital, Baltimore, USA, 3/23/2024).
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