ArticleAnnals of medicine2025
Analyzing the global burden of 11 subtypes of congenital birth defects: trends, sociodemographic correlates, and outcomes from 1990 to 2021.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Temporal trends and maternal factors associated with congenital anomalies among live births in São Paulo, Brazil: a population-based study, 2015-2023.BMC pregnancy and childbirth · 2026Article
- Large population-based assessment of SARS-CoV-2 teratogenicity by profiling congenital anomalies during COVID-19 pandemic.Journal of the Turkish German Gynecological Association · 2026Article
- Maternal exposure to ambient air pollution and risk of congenital limb defects in offspring.Scientific reports · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCongenital birth defects (CBDs) significantly affect child mortality and disability worldwide, yet regional understandings of their burden and contributing factors remain poorly defined. This study examines global trends in prevalence, disability-adjusted life years (DALYs), and mortality related to CBDs and their 11 subtypes from 1990 to 2021.
methodsEmploying data from the Global Burden of Disease Study 2021, this cross-sectional analysis covers CBD prevalence, mortality, and DALYs among children aged 0-14 years. It also investigates relationships between these trends and the Socio-Demographic Index (SDI), employing advanced statistics like Joinpoint regression and heatmap analyses to elucidate geographic variations.
resultsFrom 1990 to 2021, global trends in CBD prevalence, mortality, and DALYs generally decreased. The neonatal period (<28 days) presented the highest risk, with notable prevalence, mortality, and DALY rates. Among the 11 subtypes, congenital musculoskeletal and limb anomalies were most prevalent, while Turner syndrome was least common. Congenital heart anomalies recorded the highest mortality and DALYs. There was a negative correlation between CBD burden and SDI.
conclusionThe study underscores the global impact of CBDs on child health, pointing to significant regional disparities linked to socioeconomic factors. The findings advocate for enhanced prevention and management strategies specifically designed for regions with lower SDIs.
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