Evidence map›Paper›PMID 40528230›Full record

ArticleBiology of sex differences2025

Association between serum testosterone and measures of cardiovascular health among transgender individuals using gender-affirming testosterone therapy: a cross-sectional study.

Badal S B Pattar, Tyrone G Harrison, Nathalie Saad, Sandra M Dumanski, A J Lowik, Paul E Ronksley, Dina N Greene, Cameron T Whitley, Chantal L Rytz, Keila Turino Miranda and 4 more

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Article in Biology of sex differences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Badal S B PattarCumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Tyrone G HarrisonCumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Nathalie SaadCumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Sandra M DumanskiCumming School of Medicine, University of Calgary, Calgary, AB, Canada.
A J LowikDepartment of Sociology, University of Lethbridge, Lethbridge, AB, Canada.
Paul E RonksleyCumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Dina N GreeneDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Cameron T WhitleyDepartment of Sociology, Western Washington University, Bellingham, Washington, USA.
Chantal L RytzCumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Keila Turino MirandaCardiovascular Health and Autonomic Regulation Laboratory, Department of Kinesiology and Physical Education, McGill University, Montreal, QC, Canada.
Lindsay PeaceSkipping Stone Foundation, Calgary, AB, Canada.
Amelia M NewbertSkipping Stone Foundation, Calgary, AB, Canada.
Darlene Y SolaCumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Sofia B AhmedCumming School of Medicine, University of Calgary, Calgary, AB, Canada. Sofia.Ahmed@albertahealthservices.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGender-affirming testosterone therapy (GATT) use may be associated with increased systolic blood pressure (SBP). The association between serum testosterone and cardiovascular health in individuals using GATT is unknown. The objective of this study was to estimate the association between serum testosterone and validated measures of cardiovascular health, including SBP and arterial stiffness, in persons assigned female sex at birth using GATT.

methodsHealthy participants assigned female sex at birth on a stable GATT regimen for ≥ 4 months were recruited to this community-partnered exploratory cross-sectional study. Exposures of interest were total and free serum testosterone concentration. As our primary outcome, SBP was measured by an automated sphygmomanometer, and carotid-radial pulse wave velocity (PWVcr) and aortic augmentation index (AIx) were used to measure arterial stiffness via applanation tonometry.

resultsParticipants (n = 18, median age 28 years, range: 18, 50) who predominantly self-identified as white (94%) and had been using GATT for a median of 48 months (range: 5, 84) were studied. Resting SBP, PWVcr, and AIx were 113 mmHg (range: 102, 129), 7 m/s (range: 4, 9), and 9% (range: - 10, 23), respectively. Total and free serum testosterone were not significantly associated with SBP or PWVcr. Free, but not total, serum testosterone was positively associated with AIx (p = 0.03). Sensitivity analyses did not modify any results.

conclusionsIn healthy transgender individuals, serum testosterone concentrations may not be associated with measures of cardiovascular health. However, these results need to be interpreted with caution given the limited sample size.

Indexed as

Blood PressureTestosteroneTransgender PersonsVascular StiffnessAdolescentAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedPulse Wave AnalysisYoung AdultTestosteroneArterial stiffnessBlood pressureCardiovascular healthGender-affirming hormone therapySerum testosteroneTestosteroneTransgender

Identifiers

PMID40528230
PMCPMC12172241

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.