Omega-3 fatty acids improves tamoxifen-induced sexual dysfunction in male Wistar rats by modulating NO/cGMP signaling and monoamine neurotransmitters activities.

Adeyemi Fatai Odetayo, Roland Eghoghosoa Akhigbe, Moses Agbomhere Hamed, Afsat Motunrayo Busari, Aishat Oladoyin Ojewale-Jimoh, David Tolulope Oluwole, Adeyemi Fatai Odetayo

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Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 · What the graph read from it

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1 citing paper in PubMed.

Omega-3 fatty acids attenuate alterations in penile erectile response by enhancing sexual behavior, nitric oxide-mediated signaling, and penile antioxidant status in tamoxifen-exposed rats.BMC pharmacology & toxicology · 2026
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7 authors.

Adeyemi Fatai OdetayoDepartment of Physiology, Faculty of Basic Medical Sciences, Federal University of Health Sciences, Ila Orangun, Nigeria. adeyemiodetayo@gmail.com.ORCID http://orcid.org/0000-0002-9089-7610

Roland Eghoghosoa AkhigbeReproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Nigeria.

Moses Agbomhere HamedDepartment of Medical Laboratory Science, Afe Babalola University, Ado-Ekiti, Nigeria.

Afsat Motunrayo BusariDepartment of Physiology, Faculty of Basic Medical Sciences, Federal University of Health Sciences, Ila Orangun, Nigeria.

Aishat Oladoyin Ojewale-JimohDepartment of Physiology, Faculty of Basic Medical Sciences, Federal University of Health Sciences, Ila Orangun, Nigeria.

David Tolulope OluwoleDepartment of Physiology, Crescent University, Abeokuta, Nigeria.

Adeyemi Fatai OdetayoDepartment of Physiology, Faculty of Basic Medical Sciences, Federal University of Health Sciences, Ila Orangun, Nigeria.

Funding

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6 · The paper itself

Abstract

introductionTamoxifen (TAM) is an off-label treatment option for men with breast cancer, infertility, and gynecomastia. Unfortunately, one of the undesirable effects of TAM is sexual dysfunction. Therefore, this study was designed to investigate the possible associated mechanisms with TAM-induced sexual dysfunction and the possible ameliorative effect of omega-3 fatty acids (O3FA). METHODOLOGY: Animals were randomly divided into control, O3FA, TAM, and TAM + O3FA. All treatment lasted for 28 days.

resultsTAM exposure impaired sperm qualities (count, motility, viability, and normal morphology) and led to a decline in serum testosterone and an increase in luteinizing hormone, follicle-stimulating hormone, prolactin, and estradiol. Furthermore, TAM led to an increase in mount, intromission, and ejaculation latencies and a decrease in their corresponding frequencies. It also led to a decrease in motivation to mate and an increase in post-ejaculatory interval. These events were associated with impaired pregnancy outcomes, hormonal imbalance, a decrease in nitric oxide/cyclic cyclic guanosine monophosphate and dopamine and an increase in acetylcholine esterase and serotonin activities. These observed TAM-induced sexual dysfunction markers were ameliorated in animals that received O3FA and TAM co-treatment.

conclusionsO3FA ameliorates TAM-induced sexual dysfunction.

Indexed as

Biogenic MonoaminesFatty Acids, Omega-3Nitric OxideSexual Dysfunction, PhysiologicalTamoxifenAcetylcholinesteraseAnimalsCyclic GMPEstradiolFemaleLuteinizing HormoneMaleNeurotransmitter AgentsPregnancyRatsRats, WistarAcetylcholinesteraseBiogenic MonoaminesCyclic GMPEstradiolFatty Acids, Omega-3Luteinizing HormoneNeurotransmitter AgentsNitric OxideTamoxifenTestosteroneBreast cancerErectile dysfunctionLibidoPenile erectionSelective estrogen receptor modulatorsSexual desire

Identifiers

PMID40528104

DOI10.1007/s00213-025-06836-5

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