ArticleAnnals of biomedical engineering2025
Orientation-Independent T2 Mapping Enhances MRI-Based Cartilage Characterization.
Article in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Reproducibility of T2 relaxation time mapping in a phantom and human knee articular cartilage.Magma (New York, N.Y.) · 2026Article
- Machine learning assisted prediction of cartilage histology using MR fingerprinting - a preliminary study.Magma (New York, N.Y.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
purposeQuantitative T2 mapping is an important MRI method for assessing degenerative changes in articular cartilage. Recently, in a measurement setup with automated sample re-orientation, it was demonstrated that T2 can be split into its orientation-independent components. This quantitative MRI study aims to assess the diagnostic significance of the automated approach with ex vivo human cartilage.
methodsT2 maps of 30 human osteochondral samples harvested from 5 cadaveric individuals were acquired at 9.4T in 13 orientations, allowing calculation of the T2 components. Additionally, T1, adiabatic T1ρ, and continuous wave T1ρ with two spin-lock frequencies were scanned in a single orientation. For reference, the collagen network anisotropy, proteoglycan content and biomechanical indentation properties were measured. The relationships between quantitative MRI and reference parameters were studied using Mann-Whitney U-test and Spearman's rank correlation. All parameters were compared between healthy and degenerated groups based on OARSI grading.
resultsThe anisotropic relaxation rate component of T2 (R2a), and all T1 and T1ρ parameters differed (p < 0.05) between the groups in superficial cartilage. R2a correlated moderately with PLM anisotropy (r = 0.44) and optical density (r = - 0.37) in the deep zone. Isotropic T2 component (R2i) correlated with instantaneous modulus (r = 0.48), and R2a with phase shift between stress and strain during indentation testing (r = - 0.44). T1 and T1ρ parameters correlated with both, instantaneous and dynamic modulus in several zones of cartilage.
conclusionThe elevation of T2 in degenerated cartilage is primarily driven by the R2a component, whereas the R2i component showed no significant difference between healthy and degenerated human articular cartilage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.