Evidence map›Paper›PMID 40528069›Full record

ArticleEuropean journal of drug metabolism and pharmacokinetics2025

Tacrolimus Trough Concentrations are Not Impacted by Epstein-Barr Virus Serology and Viral Load in Pediatric Liver Transplant Recipients.

Amber M Te Lintelo, Lisa F van Wier, Hubert P J van der Doef, Jos G W Kosterink, René Scheenstra, Coretta C van Leer, Arno R Bourgonje, Daan J Touw, Paola Mian

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Article in European journal of drug metabolism and pharmacokinetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Amber M Te Lintelo *Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Lisa F van Wier *Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Hubert P J van der DoefDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Jos G W KosterinkDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
René ScheenstraDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Coretta C van LeerDepartment of Medical Microbiology (Clinical Virology), University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Arno R BourgonjeDepartment of Gastroenterology and Hepatology, University Medical Center GroningenUniversity of Groningen, Groningen, The Netherlands.
Daan J TouwDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Paola MianDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands. p.mian@umcg.nl.ORCID http://orcid.org/0000-0002-3551-1201

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesEpstein-Barr virus (EBV) is a common herpesvirus among pediatric liver transplant recipients, but it can have serious complications, such as post-transplant lymphoproliferative disease. EBV is hypothesized to influence tacrolimus concentrations by increasing inflammatory cytokines that regulate the expression of cytochrome-P-450 enzymes involved in tacrolimus pharmacokinetics. This study aims to examine the association between EBV serostatus and viral load, and tacrolimus trough concentrations corrected for the dose and recipient weight [weight-adjusted concentration-to-dose (C/D) ratios]. MATERIALS AND

methodsThis retrospective study includes pediatric liver transplant recipients aged 0-18 years old, transplanted at the University Medical Center Groningen between January 2008 and September 2021. This study utilized two cohorts: a cross-sectional and a longitudinal study database.

resultsThe association between EBV serostatus and the tacrolimus pharmacokinetics was examined using 45 recipients from both cohorts. The effect of EBV viral load on tacrolimus pharmacokinetics was examined using the longitudinal study database, which included 25 EBV-positive recipients. No significant effect of EBV on the tacrolimus weight-adjusted C/D ratios was found, for either EBV serostatus (p = 0.85) or EBV viral load (p = 0.85).

conclusionsThis study suggests that the standard protocol of tacrolimus dosing does not seem to require adjustments due to changes in EBV serostatus or viral load.

Indexed as

Epstein-Barr Virus InfectionsHerpesvirus 4, HumanImmunosuppressive AgentsLiver TransplantationTacrolimusAdolescentChildChild, PreschoolCross-Sectional StudiesFemaleHumansInfantInfant, NewbornLongitudinal StudiesMaleRetrospective StudiesImmunosuppressive AgentsTacrolimus

Identifiers

PMID40528069
PMCPMC12394278

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