ArticleJournal of gastrointestinal cancer2025
Rising Incidence of Total and Early-Onset Colorectal Cancer: A Global Perspective on Burden, Risk Factors, and Projections to 2031.
Article in Journal of gastrointestinal cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Preoperative Noble and Underwood Score in Colorectal Cancer Surgery: A Stable Prognostic Marker Even among Tumor Marker-Negative Cases.JMA journal · 2026Article
- Immunotherapy resistance in colorectal cancer: therapeutic strategies and biomarker-guided approaches.Cancer cell international · 2026Review
- Cancer Patterns and Barriers to Care Among Socioeconomically Vulnerable Populations in Tripoli: A Descriptive Study from a Local NGO.Diseases (Basel, Switzerland) · 2026Article
- EGFR-Targeted Extracellular Vesicles Potentiate Doxorubicin-Induced Apoptosis and Tumor Suppression in Colorectal Cancer.International journal of molecular sciences · 2026Article
- Predicting therapeutic responses in metastatic colorectal cancer through personalized functional profiling of patient-derived spheroids.NPJ precision oncology · 2026Article
- Transformer Models, Graph Networks, and Generative AI in Gut Microbiome Research: A Narrative Review.Bioengineering (Basel, Switzerland) · 2026Review
- Bacterial extracellular vesicles in colorectal cancer: mechanisms, biomarker potential, and therapeutic engineering.Cell communication and signaling : CCS · 2026Review
- The role of PLOD family genes in liver hepatocellular carcinoma: from mechanisms to therapeutic potential.BMC cancer · 2026Article
- Optimized CNN framework with VGG19, EfficientNet, and Bayesian optimization for early colon cancer detection.Scientific reports · 2026Article
- A Lightweight Cross-Gated Dual-Branch Attention Network for Colon and Lung Cancer Diagnosis from Histopathological Images.Medical sciences (Basel, Switzerland) · 2025Article
- Clinical application of indocyanine green fluorescence imaging technology in laparoscopic rectal cancer surgery.Journal of gastrointestinal oncology · 2025Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe occurrence of colorectal cancer in those under 50 has significantly increased in recent decades. This study assesses the burden of colorectal cancer (CRC) and early-onset colorectal cancer (EO-CRC), along with associated risk factors, using data from the Global Burden of Disease (GBD) 2021, and projects incidence and mortality rates for 2031.
methodsData on prevalence, incidence, mortality, disability-adjusted life years (DALYs), and risk factors were retrieved from the GBD 2021. The average annual percentage changes (AAPCs) were calculated using joinpoint regression analysis, and projections to 2031 were made with Autoregressive Integrated Moving Average (ARIMA) models.
resultsThe number of new CRC cases globally was 2,194,143, of which EO-CRC accounted for 211,890 cases. Both CRC (AAPC 0.20) and EO-CRC (AAPC 0.99) demonstrated global increases from 1990 to 2021, with EO-CRC showing a sharper rise. The most significant increases in EO-CRC incidence, mortality, and DALYs occurred in America. Projected EO-CRC incidence and mortality rates for 2031 are 6.70 and 2.57 per 100,000 individuals, respectively. Major risk factors for CRC and EO-CRC DALYs included diets low in milk and calcium, high red meat intake, and elevated BMI.
conclusionsThis study highlights the growing EO-CRC burden, particularly in America, emphasizing the need for targeted interventions to address dietary and lifestyle risk factors. Projections indicate a continued rise in EO-CRC incidence and mortality by 2031, underscoring the urgency for public health action to mitigate this trend. The occurrence of colorectal cancer in those under 50 has significantly increased globally from 1990 to 2021, with notable regional variations. Our study assesses the current burden of CRC and EO-CRC using data from the Global Burden of Disease 2021, identifies associated risk factors, and projects incidence and mortality trends through 2031 using ARIMA models. These findings offer a precise measurement of the EO-CRC burden and underscore the necessity of identifying and addressing at-risk people to effectively mitigate this escalating health concern.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.