Evidence map›Paper›PMID 40528025›Full record

ArticleCardiovascular and interventional radiology2025

In Vitro Evaluation of Hydrogel Coils Combined with Liquid Embolic and Sclerosing Agents for Endovascular Embolization.

Akiko Narita, Hiroaki Okada, Yuki Maruchi, Kyohei Takahata, Takahiro Yamamoto, Nozomu Matsunaga, Shuji Ikeda, Masashi Shimohira, Kojiro Suzuki

Abstract read
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In one paragraph

Article in Cardiovascular and interventional radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Akiko NaritaDepartment of Radiology, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, Aichi, Japan. narita.akiko.046@mail.aichi-med-u.ac.jp.ORCID http://orcid.org/0000-0002-1229-0290
Hiroaki OkadaDepartment of Radiology, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, Aichi, Japan.
Yuki MaruchiDepartment of Radiology, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, Aichi, Japan.
Kyohei TakahataDepartment of Radiology, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, Aichi, Japan.
Takahiro YamamotoDepartment of Radiology, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, Aichi, Japan.
Nozomu MatsunagaDepartment of Radiology, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, Aichi, Japan.
Shuji IkedaDepartment of Radiology, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, Aichi, Japan.
Masashi ShimohiraDepartment of Radiology, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, Aichi, Japan.
Kojiro SuzukiDepartment of Radiology, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, Aichi, Japan.

Funding

Japan Society for the Promotion of Science JP23K14906
6 · The paper itself

Abstract

purposeHydrogel coils have expandable hydrogels that enhance the embolization effect. Hydrogel coils are sometimes used in combination with liquid embolic or sclerosing agents. This study evaluated the effect of liquid embolic and sclerosing agents on hydrogel coils. MATERIAL AND

methodsThis study consists of two experiments. (1) 0.035 inch-outward-expanding hydrogel coils were soaked in the following solutions: ethanol, 25% n-butyl-2-cyanoacrylate with lipiodol (NBCA), 5% ethanolamine oleate with iopamidol (EOI), and 3% polidocanol. Changes of the hydrogel coils were observed sequentially using a stereomicroscope. (2) Hydrogel coils were soaked in phosphate-buffered saline (pH 7.4, 37 °C) for > 30 min and then moved into the above solutions. Changes of the hydrogel coils were evaluated over time.

results(1) The primary coil diameter soaked in ethanol and NBCA did not change. The primary coil diameter soaked in EOI and polidocanol increased to 2.7 times the original value and 3.1 times, respectively, but the hydrogels cracked. (2) The primary coil diameter of expanded coils soaked in phosphate-buffered saline was 2.0 times the original value. The primary coil diameter decreased 1.0-fold in ethanol. In NBCA, frayed structures gradually appeared at the surface of the hydrogels, increasing in primary coil diameter 4.3 times, and were exposed from NBCA. The primary coil diameter soaked in EOI and polidocanol increased 2.5 times and 2.8 times, respectively, and the hydrogels cracked.

conclusionIn vitro, sclerosing agents disabled or damaged hydrogel coils. The combination of sclerosing agents and hydrogel coils might clinically have adverse effects, including the insufficient and non-target embolization.

Indexed as

Embolization, TherapeuticHydrogelsSclerosing SolutionsEnbucrilateEthanolEthiodized OilHumansIn Vitro TechniquesIopamidolMaterials TestingOleic AcidsPolidocanolPolyethylene GlycolsEnbucrilateEthanolethanolamine oleateEthiodized OilHydrogelsIopamidolOleic AcidsPolidocanolPolyethylene GlycolsSclerosing SolutionsEmbolizationEOIEthanolHydrogel coilPolidocanol

Identifiers

PMID40528025

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.