Evidence map›Paper›PMID 40528007›Full record

ArticleMikrochimica acta2025

Gold nanotriangle-enhanced high-sensitive determination of alpha-fetoprotein via lateral flow immunoassay in serum.

Chengjie Yang, Yurui Zhou, Chuan Fan, Honglu Wang, Jiaxin Xu, Zhicheng Wu, Yan Song, Yanbin Hu, Meng Tian, Guodong Liu

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chengjie Yang *School of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China.
Yurui Zhou *School of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China.
Chuan FanSchool of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China. fanchuanly@163.com.
Honglu WangSchool of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China.
Jiaxin XuSchool of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China.
Zhicheng WuSchool of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China.
Yan SongSchool of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China.
Yanbin HuSchool of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China.
Meng TianSchool of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China. tianmeng_elena@163.com.
Guodong LiuSchool of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China. liuguodong2@lyu.edu.cn.

Funding

2024 Linyi University Undergraduate Innovation and Entrepreneurship Training Program Project X202410452257Startup Foundation for Advanced Talents of Linyi University Z6122047Startup Foundation for Advanced Talents of Linyi University Z6124066
6 · The paper itself

Abstract

The first visual lateral flow immunoassay (LFIA) is reported using gold nanotriangles (AuNTs) as labeling materials for high-sensitivity alpha-fetoprotein (AFP) detection in serum. Compared with traditional gold nanoparticles, the use of anisotropic AuNTs significantly reduces the detection limit of AFP due to larger surface area and strong localized surface plasmon resonance, which can reach 5 ng/mL in serum samples with naked eyes. Under optimized conditions, this method demonstrates excellent accuracy and reproducibility in both buffer and serum systems. More importantly, the direct use of gold nanotriangles as labeling materials has the advantages of simple synthesis and strong controllability compared with complex composite labeling materials. This work pioneers the application of AuNTs in LFIA, bridging the gap between simplicity (visual readout) and high sensitivity, and provides a scalable platform for point-of-care diagnostics and is expected to have commercial application prospects.

Indexed as

alpha-FetoproteinsGoldMetal NanoparticlesHumansImmunoassayLimit of Detectionalpha-FetoproteinsGoldAlpha-fetoproteinEarly diagnosisGold nanotriangleLateral flow assayVisual detection

Identifiers

PMID40528007

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.