Evidence map›Paper›PMID 40527955›Full record

ArticleCommunications biology2025

Computational loop reconstruction based design of efficient PET hydrolases.

Hongzhao Wang, Yuntao Cun, Minxuan Wang, Xiaoyu Du, Zhenwu Yang, Hao Wang, Jun Zhang, Pengyu Wang, Yue Feng, Yushan Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hongzhao Wang *College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Yuntao Cun *College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Minxuan Wang *College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Xiaoyu Du *Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, China.
Zhenwu YangCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Hao WangBeijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, China.ORCID http://orcid.org/0000-0002-8176-9334
Jun ZhangDepartment of Chemical Engineering, Tsinghua University, Beijing, China.
Pengyu WangDepartment of Chemical Engineering, Tsinghua University, Beijing, China.
Yue FengBeijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, China. fengyue@mail.buct.edu.cn.ORCID http://orcid.org/0000-0002-1576-1385
Yushan ZhuCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China. zhuys@mail.buct.edu.cn.ORCID http://orcid.org/0000-0003-4332-4243

Funding

Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2021YFC2103600PetroChina Company Limited (PetroChina) PRIKY23109
6 · The paper itself

Abstract

Enzymatic PET depolymerization represents a promising approach for establishing a circular economy for PET plastics. Nonetheless, limitations in enzyme activity persist as significant challenges to its industrial application. In this research, the backbone structure of the β6-β7 loop for PET hydrolase Bhr-PETase derived from the thermophilic bacterium HR29 was reconstructed by introducing double mutations (H218N/F222M), resulting in variant Bhr-NMT with high thermal stability (T

Indexed as

Bacterial ProteinsHydrolasesPolyethylene TerephthalatesProtein EngineeringEnzyme StabilityMutationBacterial ProteinsHydrolasesPolyethylene Terephthalates

Identifiers

PMID40527955
PMCPMC12174350

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.