ReviewNature aging2025
Skin health and biological aging.
Review in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Short-term efficacy and safety of 5MHz fractional microneedle radiofrequency for facial rejuvenation: a prospective study.Annals of medicine · 2026Trial
- A self-assembled Dendrobium polysaccharide hydrogel with anti-aging activity via the FOXO signaling pathway.Natural products and bioprospecting · 2026Article
- Electroresponsive hyaluronic acid click hydrogels for combined antibacterial delivery and wound healing applications.Materials & design · 2026Article
- Article
- Impact of the Composition of Cosmetic Formulations on the Skin Barrier and Film-Forming Potential of a Skin-Protective Biopolymer.ACS omega · 2026Article
- Developing an Analytical Framework for the Molecular Weight Analysis of Fish-Derived Collagen Peptides in Beverages: A Multi-Method Comparative Study.Food science & nutrition · 2026Article
- Skin aging: mechanisms, evaluation, and rejuvenation.The EMBO journal · 2026Review
- Multi-omic analysis reveals Wharton's jelly mesenchymal stem cells shift the pro-inflammatory phenotype of fibroblast subpopulation to induce skin rejuvenation.Cell & bioscience · 2026Article
- Single-Cell Transcriptomic Mapping of PD-L1/TLR4 Remodeling Informs Topical Immunoprevention Timing in Skin Carcinogenesis.bioRxiv : the preprint server for biology · 2026Article
- An Injectable Biopolymer Hydrogel Complex (PN/HA/B3) for Facial Skin Redensification and General Rejuvenation: Clinical Report on Device Safety and Efficacy.Journal of functional biomaterials · 2026Article
- A self-powered chloroplast-driven nanophotosystem for treating skin photoaging through rejuvenating mitochondria and revitalizing senescent fibroblasts.Journal of nanobiotechnology · 2026Article
- Commentary to Single-Cell Transcriptomics Reveal Human Skin Pathways and Introduction of a New Dior Skin Longevity Compass™.Journal of cosmetic dermatology · 2026Article
- Single-Cell Transcriptomics Reveal Human Skin Aging Pathways.Journal of cosmetic dermatology · 2026Article
- Rosemary Aqueous Extract as a Natural Alternative to Retinol for Skin Aging Intervention.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Functionally Graded Surfaces and Materials: From Fabrication to Biomedical Applications.Chemical reviews · 2026Review
- Article
- Harnessing phytochemicals for engineering health solutions.Human genomics · 2026Review
- Decreased S100A7 expression is linked to altered differentiation-, autophagy- and senescence-related programs during skin aging.npj aging · 2026Article
- Article
- Effects of Kiperin Elixea, a multicomponent antioxidant supplement, on redox homeostasis and longevity-associated gene expression in human epithelial cell models.Frontiers in aging · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
Accumulating evidence indicates that biological aging can be accelerated by environmental exposures, collectively called the 'exposome'. The skin, as the largest and most exposed organ, can be viewed as a 'window' for the deep exploration of the exposome and its effects on systemic aging. The complex interplay across hallmarks of aging in the skin and systemic biological aging suggests that physiological processes associated with skin aging influence, and are influenced by, systemic hallmarks of aging. This bidirectional relationship provides potential avenues for the prevention of accelerated biological aging and the identification of therapeutic targets. We provide a review of the interactions between skin exposure, aging hallmarks in the skin and associated systemic changes, and their implications in treatment and disease. We also discuss key questions that need to be addressed to maintain skin and overall health, highlighting the need for the development of precise biomarkers and advanced skin models.
Indexed as
Identifiers
40527938What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.