Evidence map›Paper›PMID 40527905›Full record

ArticleNPJ Parkinson's disease2025

The East London Parkinson's disease project - a case-control study of Parkinson's Disease in a diverse population.

Alexandra Zirra, Kamalesh C Dey, Ellen Camboe, Sheena Waters, Tahrina Haque, Brook Huxford, Harneek Chohan, Natalie Donkor, Joshua Kahan, Aaron Ben-Joseph and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Alexandra Zirra *Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Kamalesh C Dey *Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Ellen CamboeCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Sheena WatersCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Tahrina HaqueCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Brook HuxfordCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Harneek ChohanCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Natalie DonkorCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Joshua KahanCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Aaron Ben-JosephCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
David A GallagherNeurology Department, Royal London Hospital, Barts Health NHS Trust, London, UK.
Caroline BuduNeurology Department, Royal London Hospital, Barts Health NHS Trust, London, UK.
Thomas BoyleCare of the Elderly Department, Royal London Hospital, Barts Health NHS Trust, London, UK.
Cristina SimonetCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Andrew J LeesRita Lila Weston Institute of Neurological Studies, University College London, London, UK.
Charles R MarshallCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Alastair J NoyceCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK. a.noyce@qmul.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a relative dearth of research on patients with Parkinson's disease (PD) from under-represented ethnic groups in the United Kingdom. The East London Parkinson Disease project seeks to understand the clinical manifestations and determinants of PD in a diverse population. Data on clinical features were collected, between 2019 and 2024. We assessed 218 patients with PD and 90 controls. Among them, 50% of patients and 64% controls identified as South Asian or Black. South Asian and Black patients had significantly worse motor scores compared to White patients (mean [SD], 42.2 [18.8], and 47.0 [16.6] vs 35.2 [16.4], p < 0.001 and p < 0.001). Cognitive impairment was more prevalent in South Asian (73%) and Black patients (75%) than in White patients (45%, p = 0.002). Our results suggest that patients with PD from South Asian and Black ethnic groups may have more severe motor and certain non-motor features, including cognitive impairment, compared to White patients.

Identifiers

PMID40527905
PMCPMC12174313

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.