Trial reportMedicine2025
Skin cooling and topical application of menthol can reduce propofol injection-induced pain, a randomized trial.
Trial report in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSkin cooling has an analgesic effect on propofol injection-induced pain. We evaluated the analgesic effectiveness of topical menthol application and skin cooling for reducing propofol injection-induced pain.
methodsPatients (n = 120) were randomized to a cooling group, a room temperature group (non-cooling group), a menthol group, and a solvent group. In the cooling group, a cooling gel pad (7°C) was applied to the forearm. In the non-cooling group, a gel pad (25°C) was used. In the menthol group, 30% menthol was applied to the forearm. In the solvent group, a solvent was applied. Fifteen minutes after these interventions, propofol was intravenously injected. We assessed the incidence and severity of propofol injection-induced pain.
resultsThe incidence of propofol injection-induced pain in the cooling group was significantly lower than that in the non-cooling group (27% vs 52%, P = .049). The pain intensity in the cooling group was lower than that in the non-cooling group (P = .027). The incidence of propofol injection-induced pain in the menthol group was significantly lower than that in the solvent group (13% vs 40%, P = .020). The pain intensity in the menthol group was lower than that in the solvent group (P = .021).
conclusionTopical menthol application and skin cooling are effective for reducing propofol injection-induced pain.
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