Observational studyMedicine2025
Oral tranexamic acid, low-fluence intense pulsed light, and glycolic acid for the treatment of mixed melasma: An observational study.
Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
This study aimed to compare the efficacy and safety of triple therapy with oral tranexamic acid (TA), low-fluence intense pulsed light (IPL), and glycolic acid (GA) peels versus the same regimen without GA for treating mixed melasma. Patients with mixed melasma were randomly divided into 2 groups, with 20 patients in each group. The treatment duration was 4 months. Group A received oral TA (250 mg twice daily) combined with 2 sessions of low-fluence IPL per month (at a 2-week interval). Group B was treated with TA in combination with low-fluence IPL following the same procedure and weekly alternating treatment with GA. Both groups underwent a total of 8 IPL sessions over the course of the treatment. Patients were followed monthly for 3 months. At the end of the treatment, group B showed a lower mean modified Melasma Area and Severity Index (mMASI) score (3.14 ± 1.84) compared with group A (4.11 ± 2.05). The mean percentage improvement in mMASI scores was 46.81 ± 11.1 for group A and 60.70 ± 10.9 for group B (P < .05). Both groups exhibited a significant reduction in telangiectasia. Combining low-fluence IPL and GA with oral TA resulted in better cosmetic improvement than the treatment combination without GA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.