Evidence map›Paper›PMID 40527740›Full record

ArticleKorean journal of radiology2025

Multiparametric MRI for Diagnosing Dysthyroid Optic Neuropathy: Added Value of Magnetization Transfer Imaging.

Jiang Zhou, Quan Yuan, Xiong-Ying Pu, Jin-Ling Lu, Hu Liu, Huan-Huan Chen, Xiao-Quan Xu, Hao Hu, Fei-Yun Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Korean journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiang Zhou *Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0003-1038-387X
Quan Yuan *Department of Radiology, The People's Hospital of Danyang, Zhenjiang, China.ORCID https://orcid.org/0009-0005-8184-7258
Xiong-Ying PuDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0009-0007-7166-4030
Jin-Ling LuDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0009-0000-1037-1807
Hu LiuDepartment of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0002-5545-3926
Huan-Huan ChenDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0003-0201-2059
Xiao-Quan XuDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0001-5493-5256
Hao HuDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. haohu_njmu@163.com.ORCID https://orcid.org/0000-0002-7983-7377
Fei-Yun WuDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. wfy_njmu@163.com.ORCID https://orcid.org/0000-0002-3479-369X

Funding

Jiangsu Commission of Health MQ2024050Jiangsu Province Hospital JSPH-MC-2021-8Jiangsu Province Postgraduate Research and Practical Innovation Plan Project JX12314332Science, Technology and Education JSDW202243
6 · The paper itself

Abstract

objectiveTo evaluate the ability of magnetization transfer imaging (MTI) to diagnose dysthyroid optic neuropathy (DON) and to establish the added value of MTI to conventional T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI). MATERIALS AND

methodsOne hundred and forty-nine patients with thyroid-associated ophthalmopathy were included and divided into training (46 eyes with DON and 148 eyes without DON) and validation (20 eyes with DON and 64 eyes without DON) cohorts. The orbital magnetic resonance imaging (MRI) protocols included coronal MTI, fat-suppressed T2WI, and DWI. The minimum, mean, and maximum values of the magnetization transfer ratio (MTR), signal intensity ratio (SIR), apparent diffusion coefficient (ADC) of each optic nerve (ON), and modified muscle index (mMI) of each orbit were calculated and compared between the groups. Multi-variable logistic regression analysis was performed to identify the independent imaging predictors of DON. The performance of each imaging predictor and their combinations using a binary logistic regression model for diagnosing DON was evaluated using receiver operating characteristic (ROC) curve analysis.

resultsEyes with DON exhibited significantly lower MTRs and ADCs of the ON, increased SIRs of the ON, and increased mMI. The MTR

conclusionMTI may be a useful non-invasive technique for diagnosing DON. MTR can provide additional value to conventional DWI in distinguishing patients with DON from those without DON.

Indexed as

Graves OphthalmopathyMultiparametric Magnetic Resonance ImagingOptic Nerve DiseasesAdultAgedDiffusion Magnetic Resonance ImagingFemaleHumansMaleMiddle AgedRetrospective StudiesROC CurveSensitivity and SpecificityDysthyroid optic neuropathyMagnetic resonance imagingMagnetization transferOptic nerve

Identifiers

PMID40527740
PMCPMC12235550

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.