ArticleMacromolecular rapid communications2025
Lipoic Acid Based Redox-Responsive Degradable Antimicrobial Polymers.
Article in Macromolecular rapid communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Sulfonium-Based Antimicrobial Block Copolymers: Influence of Hydrophobicity on Biological Activity and Antibiotic Synergy.Macromolecular rapid communications · 2026Article
- Degradable Vinyl-Based Polymers by Radical Ring-Opening Polymerization: A User Guide.ACS polymers Au · 2026Article
- Membrane-Focused Strategies AgainstAntibiotics (Basel, Switzerland) · 2026Review
- Dual-Pathway Strategy for Click-Type Functionalization and Programmable Polymer Deconstruction.Macromolecules · 2026Article
- Oxygen-Tolerant, Red Light-Driven Controlled Synthesis of Easily Degradable and High Molecular Weight α-Lipoic Acid-Vinyl Copolymers.Angewandte Chemie (International ed. in English) · 2025Article
- Lipoic Acid Based Redox-Responsive Degradable Antimicrobial Polymers.Macromolecular rapid communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The rise of multidrug-resistant (MDR) pathogens poses a critical threat to global health, exacerbated by the overuse of antibiotics and the lack of effective alternatives. Antimicrobial peptides (AMPs) have emerged as promising candidates due to their broad-spectrum activity and unique mechanisms of action. However, several challenges such as enzymatic degradation, high production costs, and potential cytotoxicity have hindered their clinical translation. To overcome these limitations, antimicrobial polymers (APs) inspired by AMPs have been developed using controlled/living polymerization techniques. In this study, a series of degradable, disulfide-containing antimicrobial polymers incorporating benzyl lipoate, a lipoic acid (LA) derivative, is synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. Benzyl lipoate is prepared by modification of LA with benzyl alcohol to introduce a hydrophobic moiety and copolymerized with a primary amine-containing cationic monomer and hydrophilic co-monomers, including hydroxyethyl acrylamide (HEAm) and poly(ethylene glycol) methyl ether acrylate (PEGMEA). The resulting polymers demonstrated antimicrobial activity against drug-resistant Pseudomonas aeruginosa, improved hemocompatibility, and redox-responsive degradability. This study highlights the potential of disulfide-based APs as a next-generation strategy for combating MDR infections while ensuring controlled degradability.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.