Evidence map›Paper›PMID 40527595›Full record

ArticleClinical medicine & research2025

A Case of Methemoglobinemia and Hemolysis from Sodium Chlorite Ingestion.

Jessica Liu, Matthew Patel, Marisa Vigna, Mark Keith Hewitt, Wendy Lim

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PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical medicine & research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jessica LiuDepartment of Medicine, Western University, London, ON, Canada.
Matthew PatelDepartment of Medicine, University of Toronto, Toronto, ON, Canada.
Marisa VignaDivision of Emergency Medicine, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Mark Keith HewittDepartment of Emergency Medicine, Department of Critical Care, Health Sciences North, Northern Ontario School of Medicine, Sudbury, ON, Canada.
Wendy LimDepartment of Medicine, McMaster University, Hamilton, ON, Canada limwp@mcmaster.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sodium chlorite is a household and industrial cleaning agent that can cause oxidative stress leading to methemoglobinemia and severe hemolysis when ingested. There is a scarcity of published literature reporting this in humans. We report a case of intentional sodium chlorite ingestion for homeopathic purposes that resulted in methemoglobinemia and hemolysis, requiring admission to the intensive care unit. Following successful treatment with methylene blue, the patient developed worsening hemolytic activity. Outpatient testing later revealed she was non- glucose-6-phosphate dehydrogenase (G6PD) deficient. Hemolysis precipitated by methylene blue is an underrecognized side effect that can be observed in individuals both with and without G6PD deficiency.

Indexed as

ChloridesHemolysisMethemoglobinemiaFemaleGlucosephosphate Dehydrogenase DeficiencyHumansMethylene BlueSodium CompoundsChlorideschloriteMethylene BlueSodium CompoundsGlucose-6-Phosphate Dehydrogenase DeficiencyHemolytic AnemiaMethemoglobinemiaMethylene Blue

Identifiers

PMID40527595
PMCPMC12172662

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.