Evidence map›Paper›PMID 40527497›Full record

ArticleMolecular pharmaceutics2025

Impact of Permeation Enhancers on the Release of Insulin from Tablets in Biorelevant Media.

Andrew Fagan, Lorraine M Bateman, Abina M Crean, Joseph P O'Shea, Lynne S Taylor

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrew FaganSSPC, the Research Ireland Centre for Pharmaceuticals, School of Pharmacy, University College Cork, Cork T12 YT20, Ireland.
Lorraine M BatemanSchool of Pharmacy, University College Cork, Cork T12 YT20, Ireland.
Abina M CreanSSPC, the Research Ireland Centre for Pharmaceuticals, School of Pharmacy, University College Cork, Cork T12 YT20, Ireland.ORCID 0000-0001-6171-0303
Joseph P O'SheaSchool of Pharmacy, University College Cork, Cork T12 YT20, Ireland.ORCID 0000-0001-5235-8723
Lynne S TaylorDepartment of Industrial and Molecular Pharmaceutics, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.ORCID 0000-0002-4568-6021

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of chemical permeation enhancers (PEs) to improve the permeation of peptides across gastric and intestinal epithelia has proven an effective strategy in the development of oral dosage forms of peptides. However, there remains a poor understanding of how the presence of PEs impacts the dissolution characteristics of oral formulations containing peptides, nor is it known how the complex composition of biological media can influence their behavior

Indexed as

InsulinTabletsAdministration, OralChemistry, PharmaceuticalDecanoic AcidsDrug LiberationHumansHydrogen-Ion ConcentrationPermeabilitySolubilitydecanoic acidDecanoic AcidsInsulinTabletsfasted state simulated intestinal fluidgastrointestinal tractpermeation enhancerssalcaprozate sodium

Identifiers

PMID40527497
PMCPMC12239073

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.