ArticleImmunity2025
ILC3s sense gut microbiota through STING to initiate immune tolerance.
Abstract read
In one paragraph
Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- ILC3s as central regulators of mucosal homeostasis and disease pathogenesis (Review).International journal of molecular medicine · 2026Review
- Metabolic stress-activated endothelial STING rewires the sinusoidal immune niche to promote MASLD progression.The Journal of clinical investigation · 2026Article
- Article
- Migration of immune cells in tumors and inflammation: molecular mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Review
- Treadmill Exercise Alleviates Motor Deficits of PD Mice via Regulating STING-Mediated Valeric Acid-Th17/Treg-IL-17A Axis.Molecular neurobiology · 2026Article
- Oxidized mtDNA Contributes to Pulmonary Inflammation and Fibrosis in Bleomycin-Induced Lung Injury.MedComm · 2026Article
- Dysfunction of mitochondria in intestinal epithelial cells: a key player in the pathogenesis of inflammatory bowel diseases.Gastroenterology report · 2026Review
- Alterations of circulating innate lymphoid cells in recent-onset type 1 diabetes.Clinical & translational immunology · 2026Article
- Targeting the cGAS-STING Pathway in Gastrointestinal Cancers: Modulating Tumor-associated Inflammation for Therapeutic Effect.Current drug targets · 2026Review
- Context-dependent roles of the gut microbiome in food allergy tolerance versus sensitization.Gut microbes · 2025Review
- Microbiota-mediated mechanisms of mucosal immunity across the lifespan.Nature immunology · 2025Review
- The gut microbiome in lung cancer: from pathogenesis to precision therapy.Frontiers in microbiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Wenqing ZhouJoan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Department of Microbiology & Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA. Electronic address: wez4003@med.cornell.edu.
Jordan Z ZhouJoan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Department of Microbiology & Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Anees AhmedJoan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Department of Microbiology & Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Myeong Joon KimJoan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Department of Microbiology & Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.
JRI Live Cell BankJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Chun-Jun GuoJoan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Department of Microbiology & Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Gregory F SonnenbergJoan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Department of Microbiology & Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA. Electronic address: gfsonnenberg@med.cornell.edu.
Funding
Regulation of protective immunity following enteric viral infectionU01AI095608 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID, SONNENBERG, GREGORY F · 2011 to 2025
$11.0MInterleukin-2 regulation of mucosal inflammationR01AI145989 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SONNENBERG, GREGORY F · 2019 to 2025
$5.3MImmune regulation of intestinal health and diseaseR01AI123368 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Gregory F Sonnenberg · 2016 to 2026
$3.6MInnate lymphoid cell regulation of the host-microbiota interactions in cancerR01CA274534 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SONNENBERG, GREGORY F · 2022 to 2025
$3.1MInnate immune regulation of neuroinflammationR01AI162936 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SONNENBERG, GREGORY F · 2021 to 2025
$3.1MNovel mechanisms protecting the gut from TNFR37AI174468 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Gregory F Sonnenberg · 2023 to 2026
$2.8MDefining a novel mechanism of mucosal healingR01AI143842 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SONNENBERG, GREGORY F · 2019 to 2023
$2.5MMolecular mechanisms behind microbiota regulation of host amino acid and glucose homeostasisR01DK135816 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI Chun-Jun Guo · 2023 to 2026
$1.9MRegulation of Enteric Nervous System Function by Group 3 Innate Lymphoid CellsF32DK136248 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZHOU, JORDAN ZHENG · 2023 to 2025
$226kDefining a novel transcriptional regulator of intestinal health and inflammationK99DK135923 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZHOU, WENQING · 2024 to 2025
$182kNCI NIH HHS R01 CA274534NIAID NIH HHS R01 AI123368NIAID NIH HHS R01 AI143842NIAID NIH HHS R01 AI145989NIAID NIH HHS R01 AI162936NIAID NIH HHS R37 AI174468NIAID NIH HHS U01 AI095608NIDDK NIH HHS F32 DK136248NIDDK NIH HHS K99 DK135923NIDDK NIH HHS R01 DK135816
Abstract
Immune tolerance to gut microbiota is necessary for health, yet the mechanisms initiating it remain elusive. We profiled MHC II
Indexed as
Gastrointestinal MicrobiomeImmune ToleranceLymphocytesMembrane ProteinsAnimalsHelicobacter hepaticusHelicobacter InfectionsImmunity, InnateMiceMice, Inbred C57BLMice, KnockoutSignal TransductionSTING ProteinT-Lymphocytes, RegulatoryMembrane ProteinsSting1 protein, mouseSTING Proteinchronic inflammationIBDILC3simmune tolerancemicrobiotaRORγt(+) antigen-presenting cellsSTING
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.