ArticleCell reports methods2025
Expansion microscopy reveals nano-scale insights into the human neuromuscular junction.
Article in Cell reports methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Muscle fibre denervation in ageing.Clinical science (London, England : 1979) · 2026Review
- Junctions in Jeopardy: the neuromuscular junction is a selective pathological target in Charcot-Marie-Tooth disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Review
- Neuromuscular Junction as a Molecular Target in Sarcopenia: Mechanisms, Therapeutic Strategies, and Future Directions.Molecular diagnosis & therapy · 2026Review
- New Insights into Neuromuscular Junction Biology: Evidence from Human and Animal Research.International journal of molecular sciences · 2026Review
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Authors and funding
7 authors.
Funding
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Abstract
The neuromuscular junction (NMJ) is a specialized synapse that relays signals from the lower motor neuron to the skeletal muscle. Here, we detail the development and application of expansion microscopy (ExM) as a highly accessible, relatively cheap, powerful, and reproducible tool with which to obtain high-resolution insights into the subcellular structure and function of NMJs from whole-mount preparations, previously only achievable using super-resolution microscopy. ExM is equally applicable to both mouse and human tissue samples, facilitating high-resolution comparative analyses. Qualitative and quantitative analysis of ExM images reveals significant differences in the distribution of acetylcholine receptors, synaptic vesicles, and voltage-gated Na
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