ArticleClinical nutrition (Edinburgh, Scotland)2025
Activating nuclear receptor subfamily 2 group F member 2 in adipocyte stem cells rescues beige adipocyte metabolism impaired by excess early-life omega-6 fatty acids.
Article in Clinical nutrition (Edinburgh, Scotland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Maternal exercise during lactation remodels obesity-associated mammary metabolism and milk fatty acids, enhancing offspring lipid oxidation.American journal of physiology. Endocrinology and metabolism · 2026Article
- Reprogramming offspring liver health: maternal indole supplementation as a preventive strategy against MASLD.EBioMedicine · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
BACKGROUND AND
aimsDevelopmental exposure to an elevated ratio of omega-6 (n6) to omega-3 (n3) fatty acids (FA) is linked to increased infant body fat and risk of future childhood obesity. We demonstrated in mice that the high n6/n3 developmental exposure reduced nuclear receptor subfamily 2 group F member 2 (NR2F2) in Adipocyte Stem Cells (ASCs), coincident with an altered ASC mitochondrial expression profile and increased white adipose accumulation in pups. This suggested that NR2F2-low ASCs might adopt a nutrient-storage phenotype. Here, we tested the hypothesis that NR2F2 is required in ASCs to undergo beige adipogenesis and metabolism needed during postnatal life for energy and thermogenesis.
methodsC57BL/6J dams were randomized to either n6-rich or balanced n6/n3 control diets at the time of mating and underwent normal gestation and parturition. On postnatal day 12 (PND12), whole-body offspring metabolism was quantified by indirect calorimetry in conjunction with
resultsExcess developmental n6-FA exposure reduced whole-body
conclusionsThese findings demonstrate that excess n6-FA developmental exposure disrupts NR2F2-mediated ASC fate determination, leading to formation of nutrient-storing, lipogenic adipocytes. This work highlights NR2F2 as an important upstream or parallel regulator necessary for beige adipogenesis and underscores its activation as a potential therapeutic approach to mitigate early-life obesity risk. GEO RECORD: GSE284936; Token = orkvgqayblshjsds.
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