Evidence map›Paper›PMID 40526791›Full record

ArticleThe Journal of organic chemistry2025

Direct, Asymmetric, and Stereodivergent Reactions of

Miguel Mellado-Hidalgo, Joan Conejos-Jalencas, Saúl F Teloxa, Andrea Suárez-Herrera, Luke McCall, Anna M Costa, Pedro Romea, Fèlix Urpí, Gabriel Aullón, Cristina Puigjaner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Asymmetric Total Syntheses of Eliglustat and C2-The Journal of organic chemistry · 2026
    Article
  2. Direct, Asymmetric, and Stereodivergent Reactions ofThe Journal of organic chemistry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Miguel Mellado-HidalgoDepartment of Inorganic and Organic Chemistry, Section of Organic Chemistry, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, Carrer Martí i Franqués 1-11, Barcelona, Catalonia 08028, Spain.
Joan Conejos-JalencasDepartment of Inorganic and Organic Chemistry, Section of Organic Chemistry, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, Carrer Martí i Franqués 1-11, Barcelona, Catalonia 08028, Spain.
Saúl F TeloxaDepartment of Inorganic and Organic Chemistry, Section of Organic Chemistry, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, Carrer Martí i Franqués 1-11, Barcelona, Catalonia 08028, Spain.
Andrea Suárez-HerreraDepartment of Inorganic and Organic Chemistry, Section of Organic Chemistry, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, Carrer Martí i Franqués 1-11, Barcelona, Catalonia 08028, Spain.
Luke McCallDepartment of Inorganic and Organic Chemistry, Section of Organic Chemistry, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, Carrer Martí i Franqués 1-11, Barcelona, Catalonia 08028, Spain.
Anna M CostaDepartment of Inorganic and Organic Chemistry, Section of Organic Chemistry, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, Carrer Martí i Franqués 1-11, Barcelona, Catalonia 08028, Spain.ORCID 0000-0003-4345-4750
Pedro RomeaDepartment of Inorganic and Organic Chemistry, Section of Organic Chemistry, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, Carrer Martí i Franqués 1-11, Barcelona, Catalonia 08028, Spain.ORCID 0000-0002-0259-9155
Fèlix UrpíDepartment of Inorganic and Organic Chemistry, Section of Organic Chemistry, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, Carrer Martí i Franqués 1-11, Barcelona, Catalonia 08028, Spain.ORCID 0000-0003-4289-6506
Gabriel AullónDepartment of Inorganic and Organic Chemistry, Section of Inorganic Chemistry, Institut de Química Teòrica i Computacional de la Universitat de Barcelona, Universitat de Barcelona, Carrer Martí i Franqués 1-11, Barcelona, Catalonia 08028, Spain.
Cristina PuigjanerX-ray Diffraction Unit, CCTiUB, Universitat de Barcelona, Carrer Solé i Sabarís 1-3, Barcelona, Catalonia 08028, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new approach to the synthesis of all of the potential stereoisomers of β-alkoxy-α-amino acids derived from phenylalanine, tyrosine, tryptophan, and other β-aryl counterparts is reported. Such a method hinges on direct and asymmetric Lewis acid-mediated aldol-like reactions of

Identifiers

PMID40526791
PMCPMC12210260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.