Evidence map›Paper›PMID 40526782›Full record

ArticlePLoS genetics2025

The PavMYB.C2-UFGT module contributes to fruit coloration via modulating anthocyanin biosynthesis in sweet cherry.

Yangang Pei, Wanjia Tang, Yidi Huang, Hongfen Li, Xiaowei Liu, Hongxu Chen, Runmei He, Wenyi Niu, Quanyan Du, Yizhe Chu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yangang PeiCollege of Horticulture, Sichuan Agricultural University, Chengdu, Sichuan, China.
Wanjia TangCollege of Horticulture, Sichuan Agricultural University, Chengdu, Sichuan, China.
Yidi HuangCollege of Horticulture, Sichuan Agricultural University, Chengdu, Sichuan, China.
Hongfen LiCollege of Horticulture, Sichuan Agricultural University, Chengdu, Sichuan, China.
Xiaowei LiuCollege of Agriculture and Horticulture, Chengdu Agricultural College, Chengdu, Sichuan, China.
Hongxu ChenCollege of Horticulture, Sichuan Agricultural University, Chengdu, Sichuan, China.
Runmei HeCollege of Horticulture, Sichuan Agricultural University, Chengdu, Sichuan, China.
Wenyi NiuCollege of Horticulture, Sichuan Agricultural University, Chengdu, Sichuan, China.
Quanyan DuCollege of Horticulture, Sichuan Agricultural University, Chengdu, Sichuan, China.
Yizhe ChuCollege of Horticulture, Sichuan Agricultural University, Chengdu, Sichuan, China.
Heng DengSchool of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan, China.
Mingchun LiuKey Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan, China.
Ronggao GongCollege of Horticulture, Sichuan Agricultural University, Chengdu, Sichuan, China.ORCID https://orcid.org/0009-0007-4417-3826

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anthocyanins, vital secondary metabolites responsible for fruit coloration and health benefits, yet the genetic mechanisms regulating anthocyanin biosynthesis in fruits remain incompletely understood. In this study, we conducted a metabolomic analysis that revealed both the total anthocyanin content and the relative abundance of individual anthocyanin species are critical contributors of the color variation observed between yellow- and dark red-fruited cultivars. Integrating transcriptomic data with metabolic profiles, we identified a gene module central to anthocyanin biosynthesis, with PavMYB.C2 emerging as a key transcriptional activator. Functional validation through overexpression and silencing of PavMYB.C2 in cherry fruit confirmed its essential role in regulating both total anthocyanin and cyanidin-3-glucoside (Cy3G) levels. Furthermore, PavMYB.C2 upregulates transcription of the anthocyanin biosynthetic gene UFGT via its serine (S) 68 residue within the MYB domain, leading to enhanced Cy3G accumulation. These findings highlight the PavMYB.C2-UFGT regulatory module as a critical determinant of fruit coloration, offering potential avenues for improving fruit quality through genetic manipulation.

Indexed as

AnthocyaninsFruitPigmentationPlant ProteinsPrunus aviumTranscription FactorsGene Expression Regulation, PlantGlucosidesAnthocyaninscyanidin-3-O-beta-glucopyranosideGlucosidesPlant ProteinsTranscription Factors

Identifiers

PMID40526782
PMCPMC12185008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.