ArticlePloS one2025
Association between dietary inflammatory and antioxidant potential and systemic inflammatory and oxidative status with the risk and severity of coronary artery disease.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Comparative Effects of Probiotics, Prebiotics, and Synbiotics on Clinical Outcomes in Coronary Artery Disease: A Systematic Review and Meta-Analysis.Probiotics and antimicrobial proteins · 2026Review
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsUnhealthy diets have pro-inflammatory properties that have been shown to contribute to coronary artery disease (CAD). The dietary inflammatory index (DII®) and the dietary antioxidant quality score (DAQS) quantify the anti-/pro-inflammatory and antioxidant potential of a diet. This study aims to investigate the association between the energy-adjusted DII (E-DIITM), DAQS, oxidant/anti-oxidant biomarkers, and CAD risk and severity. METHODS AND
resultsThis cross-sectional study investigated 158 participants for the presence and severity of CAD based on coronary angiography. E-DII and DAQS scores, malondialdehyde (MDA), total oxidant status (TOS), glutathione peroxidase (GPX) activity, total antioxidant capacity (TAC) and conventional cardiometabolic risk factors were assessed. The triglyceride-glucose (TyG) index and mean arterial pressure (MAP) were also calculated. No association was observed between the E-DII or DAQS and the presence or severity of CAD. Based on the final regression models, age (adjusted odds ratio (AOR) =1.07, P = 0.002), male sex (AOR = 5.02, P < 0.001), MAP (AOR = 1.03, P = 0.03), HDL-C (AOR = 1.04, P = 0.06) and hs-CRP (AOR = 1.06, P = 0.045) as well as TOS (AOR = 1.16, P = 0.03) and TAC (AOR = 1.51, P = 0.07) increased and GPX activity (AOR = 0.51, P = 0.07) decreased the odds of having CAD. Male sex (adjusted β (Aβ) =22.04, P < 0.001), age (Aβ = 0.87, P = 0.003), hs-CRP (Aβ = 0.72, P = 0.045) and TOS (Aβ = 2.75, P = 0.003) were associated with higher Gensini scores. Higher GPX activity (Aβ = -10.95, P = 0.03) was associated with lower Gensini scores.
conclusionBiomarkers of oxidative stress, including TOS, TAC, and GPX activity, were associated with the presence, extent or severity of coronary atherosclerosis while no associations were observed for E-DII and DAQS scores.
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