Evidence map›Paper›PMID 40526586›Full record

ArticleJCI insight2025

Large-scale survey, animal models, and computational modeling identify histological neurodegenerative biomarkers for traumatic optic neuropathy.

YiKui Zhang, BoYue Xu, ShiWei Huang, ZhaoHui Shi, Wei Xiong, Ruijun Wang, GuiQin Liu, Linlin Chen, ZhenHua Ge, YongJie Zhang and 23 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

YiKui ZhangState Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
BoYue XuState Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
ShiWei HuangDepartment of Ophthalmology, the Second Hospital of Jilin University, Changchun, China.
ZhaoHui ShiThe Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Wei XiongThe Third Xiangya Hospital of Central South University, Changshao, China.
Ruijun WangLi Huili Hospital affiliated with Ningbo University, Ningbo, China.
GuiQin LiuShenzhen Eye Hospital, Shenzhen Eye Institute, Jinan University, Shenzhen, China.
Linlin ChenThe Fourth People's Hospital of Shenyang, China Medical University, Shenyang, China.
ZhenHua GeFirst People's Hospital of Xuzhou, Xuzhou, China.
YongJie ZhangJiaxing Hospital of Traditional Chinese Medicine, Jiaxing, China.
HongLei LiuShananxi Eye Hospital, Xi'an People's Hospital, Xi'an Fourth Hospital, Affiliated People's Hospital of Northwest University, Xian, China.
BaoYun JiaThe First Affiliated Hospital of Dali University, Dali, China.
ChunXia WangDepartment of Ophthalmology, The Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Lens Research Laboratory of Liaoning Province, Shenyang, China.
HaiHong ShiEye Institute, Affiliated Hospital of Nantong University, Nantong, China.
Jun KangDepartment of Neurosurgery, Beijing Tongren Hospital, Capital Medical University, Tongren, China.
NingYu AnPeoples Hospital of Ningxia Hui Autonomous Region, Yinchuan, China.
ShuRui HuangState Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
DeFu ChenState Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
ShengHai HuangState Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
YuTing LuoState Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
MingYue LiuState Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
ZhuoWei WangState Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
ZhongHao YuState Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Jingwei ZhengState Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Wentao YanState Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Gen LiEye Hospital, State Key Laboratory of Eye Health; Institute for Advanced Study on Eye Health and Diseases and Institute for Clinical Data Science, Wenzhou Medical University, Wenzhou, China.
Hao ChenJiangsu JITRI Sioux Technologies Company, Suzhou, China.
XingGuang DengJiangsu JITRI Sioux Technologies Company, Suzhou, China.
ShiHui WeiState Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
YunHai TuState Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
EnDe WuState Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Kang ZhangEye Hospital, State Key Laboratory of Eye Health; Institute for Advanced Study on Eye Health and Diseases and Institute for Clinical Data Science, Wenzhou Medical University, Wenzhou, China.
WenCan WuState Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUNDTraumatic optic neuropathy (TON) is a leading cause of blindness following closed traumatic brain injury, with no effective treatments available. Previous interventional clinical trials were complicated by its low prevalence, variability in neurodegenerative severity, and unavailability of reliable biomarkers.METHODSWe analyzed data from 1,226 patients enrolled in the prospective National Multi-Center Collaborative Clinical Research Program of China (2017-2024) to establish a clinical profile and identify noninvasive biomarkers for neurodegenerative severity. Subgroup analysis of patients with monocular TON revealed potential biomarkers, including visual functional parameters, inner retinal thickness, and time postinjury.RESULTSThe ganglion cell complex (GCC) thickness showed a strong correlation with retinal ganglion cell somata (R² = 0.87, P < 0.0001) and axon density (R² = 0.89, P < 0.0001) in a clinically relevant large animal model. Computational analysis demonstrated that using GCC thickness as a biomarker could substantially enhance the statistical power of clinical trials (by up to 4.5-fold), as verified by real-world data.CONCLUSIONThis study presents the largest epidemiological analysis of TON to date and establishes GCC thickness as a crucial biomarker for stratifying disease severity and improving the efficiency of clinical trials.TRIAL REGISTRATIONChinese Clinical Trial Registry (ChiCTR-OOC-17013437).FUNDINGNational Key R&D Program of China (Grant No. 2022YFA1105500), Key Science and Technology Program of Wenzhou (Grant No. ZY2022021), National Natural Science Foundation of China (Grant No. 82471080).

Indexed as

Optic Nerve InjuriesAdultAnimalsBiomarkersBrain Injuries, TraumaticChinaComputer SimulationDisease Models, AnimalFemaleHumansMaleMiddle AgedProspective StudiesRetinal Ganglion CellsYoung AdultBiomarkersClinical ResearchEpidemiologyNeurodegenerationOphthalmology

Identifiers

PMID40526586
PMCPMC12288978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.