Evidence map›Paper›PMID 40526494›Full record

ArticleeLife2025

Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling.

Joseph Hanna, Yacine Touahri, Alissa Pak, Lauren Belfiore, Edwin van Oosten, Luke Ajay David, Sisu Han, Yaroslav Ilnytskyy, Igor Kovalchuk, Deborah Kurrasch and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Joseph HannaBiological Sciences, Sunnybrook Research Institute, Toronto, Canada.
Yacine TouahriBiological Sciences, Sunnybrook Research Institute, Toronto, Canada.
Alissa PakBiological Sciences, Sunnybrook Research Institute, Toronto, Canada.ORCID https://orcid.org/0009-0001-4981-1950
Lauren BelfioreBiological Sciences, Sunnybrook Research Institute, Toronto, Canada.
Edwin van OostenBiological Sciences, Sunnybrook Research Institute, Toronto, Canada.
Luke Ajay DavidBiological Sciences, Sunnybrook Research Institute, Toronto, Canada.
Sisu HanDepartment of Medical Genetics, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.
Yaroslav IlnytskyyDepartment of Biological Sciences, University of Lethbridge, Lethbridge, Canada.
Igor KovalchukDepartment of Biological Sciences, University of Lethbridge, Lethbridge, Canada.
Deborah KurraschDepartment of Medical Genetics, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.ORCID https://orcid.org/0000-0002-9945-287X
Satoshi OkawaPittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Antonio Del SolComputational Biology Group, Luxembourg Centre for Systems Biomedicine, U of Luxembourg, Esch-sur-Alzette, Luxembourg.ORCID https://orcid.org/0000-0002-9926-617X
Robert A ScreatonBiological Sciences, Sunnybrook Research Institute, Toronto, Canada.
Isabelle AubertBiological Sciences, Sunnybrook Research Institute, Toronto, Canada.
Carol SchuurmansBiological Sciences, Sunnybrook Research Institute, Toronto, Canada.ORCID https://orcid.org/0000-0003-3567-0058

Funding

CIHR PJT 180243CIHR PJT - 400973Government of Canada Canada Graduate Scholarship - DoctoralGovernment of Ontario Ontario Graduate ScholarshipUniversity of Toronto R.O. Torrance BursaryUniversity of Toronto Vision Science Research Program Scholarship
6 · The paper itself

Abstract

Metabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggesting a role in guiding cellular differentiation. Here, we show that glycolytic flux is required and sufficient to bias multipotent retinal progenitor cells (RPCs) to acquire a rod photoreceptor fate in the murine retina. In RPC-specific

Indexed as

Cell DifferentiationGlycolysisRetinaRetinal Rod Photoreceptor CellsStem CellsWnt Signaling PathwayAnimalsMiceMice, KnockoutPhosphofructokinase-2PTEN PhosphohydrolasePFKFB3 protein, mousePhosphofructokinase-2PTEN Phosphohydrolasedevelopmental biologyglycolysisintracellular pHmousephotoreceptor differentiationPtenretinal progenitor cellsWnt signaling

Identifiers

PMID40526494
PMCPMC12173459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.