Evidence map›Paper›PMID 40526364›Full record

ArticleChild psychiatry and human development2025

Cognitive Control Difficulties Differentiate Callous-Unemotional Traits from Conduct Problems: A Pre-Registered Double-Blind Randomized Controlled Trial Analysis.

Drew E Winters, Juliet Spitz, Kristen Raymond, Crystal Natvig, Rebecca Waller, Susan K Mikulich-Gilbertson, Joseph P Schacht, Joseph T Sakai

Abstract read
In one paragraph

Article in Child psychiatry and human development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Drew E WintersDepartment of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA. drew.winters@cuanschutz.edu.ORCID http://orcid.org/0000-0002-0701-9658
Juliet SpitzDepartment of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.
Kristen RaymondDepartment of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.
Crystal NatvigDepartment of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0003-0598-9236
Rebecca WallerDepartment of Psychology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-5069-1183
Susan K Mikulich-GilbertsonDepartment of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0001-9210-8884
Joseph P SchachtDepartment of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0003-4250-0495
Joseph T SakaiDepartment of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0003-1600-6100

Funding

Development of Psychopathology, Psychobiology, & BehaviorT32MH015442 · NIMH · UNIVERSITY OF COLORADO DENVER · PI JASON R TREGELLAS · 1985 to 2026
$10.2M
Risky Parenting and Temperament Pathways To Callous-Unemotional Traits In Early ChildhoodR01MH125904 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Nicholas J Wagner, Rebecca Waller · 2022 to 2026
$3.9M
Deep Brain Stimulation (DBS) For Severe Treatment Refractory Methamphetamine Use DisorderUG3DA054746 · NIDA · UNIVERSITY OF COLORADO DENVER · PI ABOSCH, AVIVA, SAKAI, JOSEPH T · 2022 to 2023
$1.4M
An exploratory randomized controlled trial of the effects of oral semaglutide on alcohol craving and consumptionR21AA031146 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI SCHACHT, JOSEPH P. · 2023 to 2023
$429k
Effects of Transcranial Magnetic Stimulation on Social Cognition, Cognitive Processing, and Functional Brain Architecture in PsychopathyK23MH139637 · NIMH · UNIVERSITY OF COLORADO DENVER · PI Drew E Winters · 2025 to 2026
$376k
NIAAA NIH HHS R21 AA031146NIAAA NIH HHS R21AA031146NIDA NIH HHS UG3 DA054746NIDA NIH HHS UG3DA054746NIMH NIH HHS K23 MH139637NIMH NIH HHS R01 MH125904NIMH NIH HHS R01MH125904NIMH NIH HHS T32 MH015442NIMH NIH HHS T32MH015442
6 · The paper itself

Abstract

Cognition's role in youth antisocial phenotypes, particularly callous-unemotional (CU) traits (e.g., lack of remorse, guilt, and empathy) and conduct problems (CP; e.g., disruptive and aggressive behaviors), remains debated. Recent findings suggest the need to distinguish inhibitory processes, as selective control (inhibiting a prepotent response for an alternative) rather than passive control (non-response action restraint) has been linked, independent of CP, to affective deficits in CU traits. However, it is not known whether CU traits relate to a general difficulty with cognitive demands or a specific impairment in selective control. The present study tested whether CU traits were differentially related to passive versus selective control, accounting for CP. Using a randomized parallel-arm trial with test and control groups, data from 85 participants (aged 12-14, 47% female) were analyzed with mixed effects models to account for individual variance. Results indicated that CU traits were associated with better passive control but worse selective control, while CP showed no significant effects when CU traits were included. This pattern was consistent across accuracy, reaction times, and contrasts between trial types (e.g., selective > passive). Further analyses suggested that CU traits were linked to a rigid cognitive style specifically during selective control trials. These findings highlight a selective control deficit unique to CU traits, distinguishing them from CP. Moreover, evidence of a rigid cognitive strategy aligns with research on adult psychopathy, suggesting potential difficulties with cognitive resource allocation. Thus, selective control may be an important feature for understanding antisocial etiological pathways.

Indexed as

AdolescenceCallous-unemotional traitsCognitive controlConductSelective control

Identifiers

PMID40526364
PMCPMC13322642

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.