Evidence map›Paper›PMID 40526340›Full record

ReviewHead and neck pathology2025

Oral Soft Tissue and Jawbone Sarcomas: A Retrospective Clinicopathologic Analysis of 128 Cases from Two Institutions and Comprehensive Literature Review.

Prokopios P Argyris, Gabrielle R Dennis, Rajaram Gopalakrishnan, Ioannis G Koutlas, Kristin K McNamara, John R Kalmar

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Head and neck pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Prokopios P ArgyrisDivision of Oral and Maxillofacial Pathology, The Ohio State University College of Dentistry, Postle Hall, Room 2191, 305 W. 12th Avenue, Columbus, OH, 43210, USA. argyris.2@osu.edu.ORCID http://orcid.org/0000-0002-5965-6181
Gabrielle R DennisDepartment of Oral and Maxillofacial Surgery, Loma Linda University School of Dentistry, Loma Linda, CA, USA.
Rajaram GopalakrishnanDivision of Oral and Maxillofacial Pathology, School of Dentistry, University of Minnesota, Minneapolis, MN, USA.
Ioannis G KoutlasDivision of Oral and Maxillofacial Pathology, School of Dentistry, University of Minnesota, Minneapolis, MN, USA.
Kristin K McNamaraDivision of Oral and Maxillofacial Pathology, The Ohio State University College of Dentistry, Postle Hall, Room 2191, 305 W. 12th Avenue, Columbus, OH, 43210, USA.
John R KalmarDivision of Oral and Maxillofacial Pathology, The Ohio State University College of Dentistry, Postle Hall, Room 2191, 305 W. 12th Avenue, Columbus, OH, 43210, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOral soft tissue and jawbone sarcomas (OSTJS) are rare neoplasms accounting for only 1% of all intraoral malignancies. As a result, robust epidemiologic data pertaining to OSTJS are limited. Here, we present a collaborative, retrospective analysis of the clinicopathologic characteristics of 128 cases of OSTJS, together with a comprehensive review of the literature.

methodsArchived OSTJS cases (2000-2022) were retrieved from the electronic laboratory databases of the oral pathology services at The Ohio State University and University of Minnesota. Patient age and sex, anatomic site and histopathologic diagnosis were recorded.

resultsAmong 128 OSTJS, 123 (96.1%) were primary and 5 (3.9%) metastatic (M: F = 1.5:1; mean age = 43.7 years, range = 4-102 years). Most OSTJS presented in adults (113, 88.3%; mean age = 47.8 years) with only 15 pediatric cases (11.7%; mean age = 13 years). Favored sites included the mandible (48, 37.5%), maxilla (39, 30.4%), gingiva (15, 11.7%), palate (13, 10.2%), and tongue (4, 3.1%). In adults, osteosarcoma represented the predominant OSTJS (58, 51.3%), followed by Kaposi sarcoma (18, 15.9%), leiomyosarcoma (7, 6.2%), chondrosarcoma (6, 5.3%), low-grade myofibroblastic sarcoma (5, 4.4%), and 4 each (3.5%) of angiosarcoma, rhabdomyosarcoma and undifferentiated pleomorphic sarcoma. Similarly, osteosarcoma comprised the most common OSTJS histotype in the pediatric population (8, 53.3%), followed by Ewing sarcoma (4, 26.7%) and 1 each (6.7%) of TFCP2::EWSR1-rearranged rhabdomyosarcoma, mesenchymal chondrosarcoma, and alveolar soft part sarcoma.

conclusionOSTJS represent an uncommon, histopathologically diverse, subset of mesenchymal malignancies. In our series, most patients were adults in their 4th - 5th decade with a broad age range and a slight male predilection. Overall, jawbone osteosarcoma and Kaposi sarcoma accounted for two-thirds of OSTJS cases in this cohort. While the diagnosis of OSTJS relies heavily on routine light microscopic findings, ancillary immunohistochemistry and/or cytogenetic studies are frequently warranted.

Indexed as

Jaw NeoplasmsMouth NeoplasmsSarcomaSoft Tissue NeoplasmsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleHumansMaleMiddle AgedRetrospective StudiesYoung AdultJawbone sarcomaKaposi sarcomaOral cavity sarcomaOral mesenchymal neoplasmsOral soft tissue and bone malignanciesOral soft tissue sarcomaOsteosarcoma

Identifiers

PMID40526340
PMCPMC12174025

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.