ArticleEuropean geriatric medicine2025
Development and validation of a predictive nomogram for frailty based on thyroid function in older adults.
Article in European geriatric medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Longitudinal Associations Between Biomarkers and Frailty in Older Adults: Protocol for a Scoping Review.JMIR research protocols · 2026Article
- A new Drosophila model of prolonged inactivity shortens lifespan and impairs muscle function.Scientific reports · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
introductionThis study aimed to develop and validate a frailty prediction model incorporating thyroid hormone levels in older adults with normal thyroid function.
methodsA total of 767 participants aged ≥ 65 years (566 males, 73.8%) were enrolled between December 2019 and December 2023. Participants were randomly assigned to training (n = 546) and internal validation (n = 235) sets; an external validation cohort was recruited between December 2023 and December 2024. Frailty was assessed using the FRAIL scale. Predictors were selected through LASSO and logistic regression analyses, and a nomogram was constructed for clinical application.
resultsA total of 767 patients were included, with a median age of 81 years. Of these, 205 individuals (26.7%) were classified into the frailty group. The restricted cubic spline plot showed a negative correlation between the FT3/FT4 and frailty after adjusting for multiple confounding factors. Five predictors, age, polypharmacy, MNA.SF score, grip, and FT3/FT4 were incorporated to establish the model. The model performed well achieving AUC values of 0.92 and 0.80 in the development and external validation datasets, respectively. The Calibration curves and DCA results suggested that the model possesses satisfactory predictive performance.
conclusionsWe developed a clinically applicable model to predict frailty in older adults with normal thyroid function, highlighting the relevance of thyroid hormone status in frailty risk assessment.
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