Evidence map›Paper›PMID 40526331›Full record

ReviewCurrent oncology reports2025

Circulating Biomarkers in Sarcoma.

Taylor P Williams, Valerie P Grignol

Abstract readReview
In one paragraph

Review in Current oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Taylor P WilliamsDivision of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, 460 W. 10 th Ave, Columbus, OH, 43210, USA.
Valerie P GrignolDivision of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, 460 W. 10 th Ave, Columbus, OH, 43210, USA. valerie.grignol@osumc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewBiomarkers to evaluate, diagnose, and monitor cancer treatment can provide critical adjunct information to standard methods of cancer detection and monitoring. With over 100 different histologic subtypes, sarcomas are a group of tumors with a critical need for easily retrievable circulating biomarkers. This review presents the current progress in the field. We describe the myriad types of biomarkers, highlight the modalities of testing, and explore the clinical utility of specific biomarkers. RECENT

findingsGenomic circulating biomarkers include circulating tumor DNA and micro-RNA. Genomic expressions for different histologic subtypes of sarcoma are highlighted in this review. We also explore different oncogenes, their respective proteins, extracellular vesicles, and dysregulated metabolites as investigational circulating biomarkers for diagnostic and prognostic purposes. Soft tissue sarcomas are a category of cancers that lack a clinically validated circulating biomarker, and this review presents the ongoing research efforts to establish a genomic, proteomic, or metabolic biomarker.

Indexed as

Biomarkers, TumorSarcomaCirculating Tumor DNAHumansMicroRNAsPrognosisBiomarkers, TumorCirculating Tumor DNAMicroRNAsBiomarkersCtDNAExtracellular vesiclesSarcoma

Identifiers

PMID40526331
PMCPMC12423128

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.