Evidence map›Paper›PMID 40526319›Full record

ArticleDigestive diseases and sciences2025

Association Between CDK4/CDK6 Expression and Prognosis in Patients with Adenocarcinoma of Gastroesophageal Junction.

Ceng Cai, Yilidana Sitiwaerdi, Wanyi Zhang, Min Xia, Rui Mao

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Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Ceng Cai *Cancer Center, The First Affiliated Hospital of Xinjiang Medical University, No. 137 Liyushan Road, Urumqi, 830054, Xinjiang, China.
Yilidana Sitiwaerdi *Cancer Center, The First Affiliated Hospital of Xinjiang Medical University, No. 137 Liyushan Road, Urumqi, 830054, Xinjiang, China.
Wanyi ZhangCancer Center, The First Affiliated Hospital of Xinjiang Medical University, No. 137 Liyushan Road, Urumqi, 830054, Xinjiang, China.
Min XiaCancer Center, The First Affiliated Hospital of Xinjiang Medical University, No. 137 Liyushan Road, Urumqi, 830054, Xinjiang, China.
Rui MaoCancer Center, The First Affiliated Hospital of Xinjiang Medical University, No. 137 Liyushan Road, Urumqi, 830054, Xinjiang, China. maorui44@sohu.com.

Funding

Xinjiang Uygur Autonomous Region Natural Science Foundation of Outstanding Young Project 2022D01E074
6 · The paper itself

Abstract

purposeLimited data are available on the relationship between expression of CDK4/CDK6 and prognosis in patients with adenocarcinoma of gastroesophageal junction (AEG).

methodsA total of 135 patients diagnosed with AEG and treated with esophagogastrostomy were included in this study. Protein expression of CDK4 and CDK6 was assayed by immunohistochemistry staining and scored by two experienced pathologists. Differences in clinicopathologic parameters were analyzed between CDK4/CDK6-positive and -negative groups by Chi-square test and Fisher's exact test. The prognostic significance of CDK4/CDK6 in overall survival (OS) and progression-free survival (PFS) was assessed using the Kaplan-Meier method and log-rank test.

resultsThe positive rates of CDK4 and CDK6 in AEG tissues were significantly higher than in adjacent tissues. CDK4 positivity was correlated with poor tumor differentiation, and CDK6 positivity was related to perineural invasion and poor tumor differentiation. There were no significant differences between CDK4/CDK6 expression and OS or PFS of AEG patients.

conclusionCDK4/CDK6 may serve as prognostic factors for poor tumor differentiation, and CDK6 may also be a prognostic marker of perineural invasion for AEG patients.

Indexed as

AdenocarcinomaCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Esophageal NeoplasmsEsophagogastric JunctionStomach NeoplasmsAdultAgedAged, 80 and overBiomarkers, TumorFemaleHumansImmunohistochemistryMaleMiddle AgedPrognosisBiomarkers, TumorCDK4 protein, humanCDK6 protein, humanCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Adenocarcinoma of gastroesophageal junctionCyclin-dependent kinasePerineural invasionTumor differentiation

Identifiers

PMID40526319

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