Evidence map›Paper›PMID 40526259›Full record

ReviewPurinergic signalling2025

State of the art indicators for imaging purinergic dynamics in vitro and in vivo.

Yumo Li, Liwan Zhang, Bohan Li, Yulong Li, Zhaofa Wu

Abstract readReview
In one paragraph

Review in Purinergic signalling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yumo Li *State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Liwan Zhang *State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Bohan LiPeking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.
Yulong LiPeking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.
Zhaofa WuState Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. wuzhaofa@genetics.ac.cn.

Funding

National Key Research and Development Program of China 2022YFE0108700National Natural Science Foundation of China 323B2032National Natural Science Foundation of China 32422031Science and Technology Innovation 2030 2022ZD0208300
6 · The paper itself

Abstract

Purinergic neurotransmission, a dynamic signaling system using adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine (ADO), uridine diphosphate (UDP), and others, plays a crucial role in brain function. Purinergic signaling is involved in regulating synaptic communication to influence sleep and neuroprotection; malfunction of purinergic signaling contributes to various neurological disorders like pain, epilepsy, and depression. Effective detection methods are crucial for a comprehensive understanding of the multifaceted roles of purinergic signaling in the brain. This review sheds light on advancements in fluorescent indicators, a powerful toolkit for visualizing purinergic activities in living animals. We explore the diverse applications of these indicators in studying purinergic transmission both in health and in diseases. Despite their current strengths, we emphasize the need for continuous development of fluorescent indicators to achieve an even more comprehensive, specific, and quantitative detection of purinergic signaling.

Indexed as

BrainReceptors, PurinergicSynaptic TransmissionAdenosine TriphosphateAnimalsHumansSignal TransductionAdenosine TriphosphateReceptors, PurinergicDynamicsImagingIndicatorsIn vivoPurinergic transmitters

Identifiers

PMID40526259
PMCPMC12454249

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.