Evidence map›Paper›PMID 40526236›Full record

ReviewJournal of assisted reproduction and genetics2025

Embryoid bodies as a model system for exploring early human embryonic development.

Daria I Zhigalina, Evgeny V Denisov, Igor N Lebedev, Nikolay A Skryabin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Exploring endometriosis through 3DMaterials today. Bio · 2026
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daria I ZhigalinaResearch Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences, Ushaika Street 10, Tomsk, 634050, Russia.
Evgeny V DenisovCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Kooperativny Str. 5, Tomsk, 634009, Russia.
Igor N LebedevResearch Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences, Ushaika Street 10, Tomsk, 634050, Russia. igor.lebedev@medgenetics.ru.ORCID http://orcid.org/0000-0002-0482-8046
Nikolay A SkryabinResearch Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences, Ushaika Street 10, Tomsk, 634050, Russia.

Funding

Tomsk National Research Medical Center of the Russian Acedemy of Sciences oncogenesis" (#24-grant-MNI)Tomsk National Research Medical Center of the Russian Acedemy of Sciences The study was supported by a grant from the Tomsk National Research Medical Center "Cellular plasticity as a general molecular program of embryo-
6 · The paper itself

Abstract

This review article aims to summarize the existing concepts related to embryoid bodies (EBs) and explore their potential as a model system for studying various aspects of human embryonic development. The review involves the collection and analysis of information about the characteristics of EBs and the properties of stem cells that give rise to them. The results show that EBs derived from pluripotent stem cells are a promising model that closely replicates processes occurring in human embryos after implantation. The review also provides a comparative analysis of the advantages and limitations of models based on induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), with particular attention given to summarizing the results of limited studies on RNA sequencing in individual cells from human and mouse EBs. In conclusion, we would like to emphasize that embryoid bodies are an effective model system for studying early human embryogenesis. This opens up new possibilities for reproductive genetics and medicine.

Indexed as

Embryoid BodiesEmbryonic DevelopmentAnimalsCell DifferentiationEmbryo, MammalianEmbryonic Stem CellsHumansInduced Pluripotent Stem CellsMiceEmbryoid bodiesEmbryonic developmentInduced pluripotent stem cellsModel systemsSingle-cell sequencingTranscriptome

Identifiers

PMID40526236
PMCPMC12423023

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.