ArticleEuropean archives of psychiatry and clinical neuroscience2026
Decreased DTI-APLS correlated with cognitive impairment in veterans with post-traumatic stress disorder.
Article in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Assessing glymphatic-associated fluid dynamics in psychiatric disorders: evidence from neuroimaging - a review.Psychoradiology · 2025Review
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8 authors.
Funding
Abstract
Post-traumatic stress disorder (PTSD) is a risk for cognitive impairment with underlying mechanism unresolved. Our study aimed to evaluate the glymphatic function in veterans with post-traumatic stress disorder (PTSD), and to explore associations between glymphatic function, sleep patterns, cerebrospinal fluid (CSF) biomarkers (Aβ, t-tau, p-tau), and cognitive impairment. In our study, we included 43 Vietnam War veterans with PTSD and 43 controls. Diffusion tensor image analysis along the perivascular space (DTI-ALPS) was calculated to reflect glymphatic function. Multiple linear regressions and mediation analyses were employed to examine the relationships between the clinician-administered PTSD scale (CAPS) scores, Pittsburgh Sleep Quality Index (PSQI), DTI-ALPS and cognitive impairment. Our study revealed that PTSD group exhibited lower DTI-ALPS (p = 0.001), higher CAPS (p < 0.001), higher PSQI (p < 0.001), and poorer cognitive performance in CDR-SoB (p = 0.019) and ADAS-Cog total 13 (p = 0.009). CAPS was significantly associated with DTI-ALPS (β = -0.0018, 95% CI: -0.0029, -0.0006, p = 0.0028). PSQI demonstrated an indirect effect (β = -0.0005, 95% CI: -0.0011, -0.0001) and mediated 21.74% effect for the relationship between CAPS and DTI-ALPS. CAPS was significantly associated with CDR-SoB and ADAS-Cog total 13 (β = 0.0067, 95% CI: 0.00087, 0.0124, p = 0.024; β = 0.058, 95% CI: 0.013, 0.103, p = 0.012). DTI-ALPS had an indirect effect (β = 0.0024, 95% CI: 0.0006, 0.0069) and mediated all effect for the relationship between CAPS and CDR-SoB. In conclusion, glymphatic system was impaired in PTSD veterans revealed by DTI-ALPS, and poor sleep quality partially mediated the relationship between PTSD severity and impaired glymphatic function. DTI-ALPS mediated the relationship between PTSD severity and cognitive impairment.
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