Evidence map›Paper›PMID 40526087›Full record

ArticleAntimicrobial agents and chemotherapy2025

Novel C5α-substituted carbapenems enhance

Eunjeong Shin, Magdalena A Taracila, Pojun Quan, Md Mahbub Kabir Khan, Jonathan Cox, Diya Patel, Khalid M Dousa, Aetan Parmar, Mary Nantongo, David C Nguyen and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Eunjeong ShinLouis Stokes Cleveland VA Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0009-0006-2472-3264
Magdalena A TaracilaLouis Stokes Cleveland VA Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Pojun QuanDepartment of Chemistry, Southern Methodist University, Dallas, Texas, USA.
Md Mahbub Kabir KhanDepartment of Chemistry, Southern Methodist University, Dallas, Texas, USA.
Jonathan CoxDepartment of Chemistry, Southern Methodist University, Dallas, Texas, USA.
Diya PatelDepartment of Chemistry, Southern Methodist University, Dallas, Texas, USA.
Khalid M DousaLouis Stokes Cleveland VA Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0003-3272-7231
Aetan ParmarOhio State University, Columbus, Ohio, USA.
Mary NantongoLouis Stokes Cleveland VA Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
David C NguyenDepartment of Pediatrics, Division of Infectious Diseases, Rush University Medical Center, Chicago, Illinois, USA.
Eric J RubinDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0001-5120-962X
Steven M HollandLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Barry N KreiswirthCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0002-0243-131X
John D BuynakDepartment of Chemistry, Southern Methodist University, Dallas, Texas, USA.ORCID 0000-0003-1007-791X
Robert A BonomoLouis Stokes Cleveland VA Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0002-3299-894X

Funding

Dissecting the molecular targets to overcome beta-lactam resistance in M. abscessus complexR01AI141805 · NIAID · HACKENSACK UNIVERSITY MEDICAL CENTER · PI BARRY Neal KREISWIRTH · 2019 to 2026
$5.1M
Carbapenemase-Stable Carbapenem Antibiotics for Treatment of Multidrug-Resistant Acinetobacter baumannii InfectionsR01AI155723 · NIAID · UNIVERSITY OF NOTRE DAME · PI BUYNAK, JOHN D, VAKULENKO, SERGEI · 2021 to 2025
$3.9M
Optimization of Atypical Antimycobacterial Carbapenem AntibioticsR01AI174599 · NIAID · SOUTHERN METHODIST UNIVERSITY · PI JOHN D BUYNAK, Konstantin V Korotkov · 2023 to 2026
$2.8M
Cystic Fibrosis Foundation 006496F223National Institute of Allergy and Infectious Diseases 1R01AI174599,1R01AI155723National Institute of Allergy and Infectious Diseases 5R01AI141805NIAID NIH HHS R01 AI141805NIAID NIH HHS R01 AI155723NIAID NIH HHS R01 AI174599
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Bacterial Agentsbeta-LactamasesCarbapenemsMycobacterium abscessusBacterial ProteinsHumansHydrolysisImipenemMicrobial Sensitivity TestsPenicillin-Binding ProteinsPeptidyl TransferasesAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsImipenemPenicillin-Binding ProteinsPeptidyl TransferasescarbapenemsL,D-transpeptidasesMycobacterium abscessuspenicillin-binding proteins

Identifiers

PMID40526087
PMCPMC12326981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.