Evidence map›Paper›PMID 40525876›Full record

ArticleMolecular and cellular biology2025

Identification of a Novel Intracellular Function of the Secreted Ribonuclease RNASE1 in Inhibiting Gene Expression.

Ragini Singh, Ahlina Archibald, Xiao Ling Li, Ravi Kumar, Shaoli Das, Erica C Pehrsson, Patrick X Zhao, Xinyu Wen, Raj Chari, Ioannis Grammatikakis and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ragini SinghRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Ahlina ArchibaldRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Xiao Ling LiRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Ravi KumarRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Shaoli DasOmics Bioinformatics Facility, Genetics Branch, CCR, NCI, NIH, Bethesda, Maryland, USA.
Erica C PehrssonOmics Bioinformatics Facility, Genetics Branch, CCR, NCI, NIH, Bethesda, Maryland, USA.
Patrick X ZhaoOmics Bioinformatics Facility, Genetics Branch, CCR, NCI, NIH, Bethesda, Maryland, USA.
Xinyu WenOmics Bioinformatics Facility, Genetics Branch, CCR, NCI, NIH, Bethesda, Maryland, USA.
Raj ChariGenome Modification Core, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Ioannis GrammatikakisRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Ashish LalRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.ORCID 0000-0002-4299-8177

Funding

Role of long non-coding RNAs in p53 signalingZIABC011646 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LAL, ASHISH · 2015 to 2025
$15.0M
Intramural NIH HHS ZIA BC011646
6 · The paper itself

Abstract

RNASE1 is a ribonuclease secreted by cells and degrades extracellular RNAs. Here, we unexpectedly found that RNASE1, in addition to being secreted, is predominantly localized to the nucleus and functions to inhibit gene expression in human colorectal cancer (CRC) cells.

Indexed as

Colorectal NeoplasmsGene Expression Regulation, NeoplasticRibonuclease, PancreaticCarrier ProteinsCell Line, TumorCell ProliferationHCT116 CellsHumansCarrier ProteinsRibonuclease, PancreaticRNH1 protein, humanColorectal cancerCRISPRiFOXA1intracellularmRNA decaymRNA degradationribonucleaseRNASE1

Identifiers

PMID40525876
PMCPMC12316042

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.