ArticleHuman brain mapping2025
Asymmetric Cingulum Bundle Connectivity Is Modulated by Paracingulate Sulcus Morphology.
Article in Human brain mapping, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- A Multimodal Deep Learning Approach for White Matter Shape Prediction in Diffusion MRI Tractography.Human brain mapping · 2025Article
- Asymmetric Cingulum Bundle Connectivity Is Modulated by Paracingulate Sulcus Morphology.Human brain mapping · 2025Article
- A nonlinear relationship of evoked responses following charge-balanced single-pulse electrical stimulation with varying pulse widths.Brain stimulationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
The cingulum bundle (CB) is a group of axons supporting connectivity among several functional brain networks relevant in healthy and diseased states. The paracingulate sulcus (PCS) is present in at least one cerebral hemisphere across 70% of the population. PCS presence versus absence is linked to differences in structure and function of the anterior cingulate cortex, though the influence of PCS on the white matter of the CB remains unknown. The objective of this work was to define the CB electrographic connectivity profile and determine the impact of PCS morphology on CB engagement. Single-pulse electrical stimulation in combination with stereo-electroencephalography recordings was used to measure neural responses to left and right CB stimulation in 19 patients undergoing intracranial monitoring for treatment of refractory epilepsy. Evoked potential responses were extracted from brain areas, and a connectivity robustness ratio was computed. Network-level responses were compared across left and right CB, and with consideration of PCS morphology. CB electrographic connectivity demonstrated leftward dominance, but this was strongly impacted by PCS morphology in both cerebral hemispheres. Maximal left CB connectivity was observed in the presence of left PCS morphology, while right CB connectivity was strongest in its absence. These data strongly suggest that bilateral CB engagement is modulated by PCS morphology in the left hemisphere. These findings are particularly relevant when considering the CB as a target for treating neuropsychiatric disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.