Evidence map›Paper›PMID 40525694›Full record

ArticleJournal of the American Chemical Society2025

Controlling Multiphase Coacervate Wetting and Self-Organization by Interfacial Proteins.

Tiemei Lu, Susanne Liese, Brent S Visser, Merlijn H I van Haren, Wojciech P Lipiński, Wilhelm T S Huck, Christoph A Weber, Evan Spruijt

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Patchy Membrane-Directed Multiphase Complex Coacervation.Journal of the American Chemical Society · 2026
    Article
  3. What is active wetting?The European physical journal. E, Soft matter · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. A molecular grammar for programmable multiphase protein-RNA vesicles.bioRxiv : the preprint server for biology · 2026
    Article
  8. Diverse, distinct, and densely packed DNA nanostar droplets.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tiemei LuInstitute for Molecules and Materials, Radboud University, Heyendaalseweg 135, Nijmegen 6525 AJ, The Netherlands.ORCID 0000-0002-7765-4761
Susanne LieseFaculty of Mathematics, Natural Science, and Materials Engineering, Institute of Physics, University of Augsburg, Universitätsstr. 1, Augsburg 86159, Germany.
Brent S VisserInstitute for Molecules and Materials, Radboud University, Heyendaalseweg 135, Nijmegen 6525 AJ, The Netherlands.ORCID 0000-0003-0850-8426
Merlijn H I van HarenInstitute for Molecules and Materials, Radboud University, Heyendaalseweg 135, Nijmegen 6525 AJ, The Netherlands.
Wojciech P LipińskiInstitute for Molecules and Materials, Radboud University, Heyendaalseweg 135, Nijmegen 6525 AJ, The Netherlands.
Wilhelm T S HuckInstitute for Molecules and Materials, Radboud University, Heyendaalseweg 135, Nijmegen 6525 AJ, The Netherlands.ORCID 0000-0003-4222-5411
Christoph A WeberFaculty of Mathematics, Natural Science, and Materials Engineering, Institute of Physics, University of Augsburg, Universitätsstr. 1, Augsburg 86159, Germany.ORCID 0000-0001-6279-0405
Evan SpruijtInstitute for Molecules and Materials, Radboud University, Heyendaalseweg 135, Nijmegen 6525 AJ, The Netherlands.ORCID 0000-0003-4793-9923

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomolecular condensates help organize biochemical processes in cells and synthetic cell analogues. Many condensates exhibit multiphase architectures, yielding compartments with distinct functions. However, how cells regulate the transformation between different multiphase architectures remains poorly understood. Here, we use multiphase coacervates as model condensates and present a new approach to control wetting and self-organization in multiphase coacervates by introducing a surface-active protein, α-synuclein (αSyn). αSyn can localize at the interface of uridine 5'-triphosphate (UTP)/poly-l-lysine (pLL)/oligo-l-arginine (R

Indexed as

alpha-SynucleinPolylysineWettabilityalpha-SynucleinPolylysine

Identifiers

PMID40525694
PMCPMC12232295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.