Evidence map›Paper›PMID 40525590›Full record

Trial reportEarly intervention in psychiatry2025

Treatment Choices for Youth at Clinical High-Risk of Psychosis: Methods of an Open Trial.

Jean Addington, Lu Liu, Amy Braun, Cari Jahraus, Kali Brummitt, Jacqueline Stowkowy

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Early intervention in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jean AddingtonDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.ORCID https://orcid.org/0000-0002-8298-0756
Lu LiuDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Amy BraunDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Cari JahrausDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Kali BrummittDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Jacqueline StowkowyDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.

Funding

Alberta Children's Hospital Foundation
6 · The paper itself

Abstract

introductionThe number of randomised controlled trials (RCT) that address the treatment of youth at clinical high-risk (CHR) of developing psychosis is few. What is most needed are clinical trials that consider the heterogenous outcomes of those at risk of psychosis. This report describes the methods of an 18-month open trial to determine the choices of and adherence to treatment of a CHR sample.

methodsThe methods of the trial including participants and the range and rationale for the measures chosen are presented, Treatment is offered as a step model.

resultsWe present descriptive baseline data on the first 50/60 participants.

conclusionThe end results of this trial will inform the design of larger RCTs for CHR youth.

Indexed as

Psychotic DisordersAdolescentChildFemaleHumansMaleRandomized Controlled Trials as TopicCBTclinical high‐riskclinical trialpsychoeducationpsychosis

Identifiers

PMID40525590
PMCPMC12172139

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.