ArticleACS synthetic biology2025
Investigating the Potential of Division of Labor in Synthetic Bacterial Communities for the Production of Violacein.
Article in ACS synthetic biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Metabolic Engineering Strategies for Flavonoid Biosynthesis in Saccharomyces cerevisiae: Current Advances and Future Perspectives.Biotechnology and bioengineering · 2026Review
- Biochemical Upcycling of PET via Glycolysis and Engineered Microbial Consortia.Microbial biotechnology · 2026Article
- A comprehensive review on violacein production by microbial fermentation.Biodesign research · 2025Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With advancements in synthetic biology and metabolic engineering, microorganisms can now be engineered to perform increasingly complex functions, which may be limited by the resources available in individual cells. Introducing heterologous metabolic pathways introduces both genetic burden due to the competition for cellular transcription and translational machinery, as well as metabolic burden due to the redirection of metabolic flux from the native metabolic pathways. Division of labor in synthetic microbial communities offers a promising approach to enhance metabolic efficiency and resilience in bioproduction. By distributing complex metabolic pathways across multiple subpopulations, the resource competition and metabolic burden imposed on an individual cell are reduced, potentially enabling more efficient production of target compounds. Violacein is a high-value pigment with antitumor properties that exemplifies such a challenge due to its complex bioproduction pathway, imposing a significant metabolic burden on host cells. In this study, we investigated the benefits of division of labor for violacein production by splitting the violacein bioproduction pathway between two subpopulations of
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Registered trials
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